Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

Kabushiki Kaisha Hayashibara Seibutsu

Hajime Aga

Toshio Miyake

Takashi Shibuya

Shigeharu Fukuda

Toshiyuki Sugimoto

Michio Kubota

Tomoyuki Nishimoto

Shuzo Sakai

Kazuyuki Oku

Tetsuya Nakada

Masaru Yoneyama

Tetsuya Ohashi

Masashi Kurimoto

Satoshi Iritani

Hikaru Masahiro Watanabe

Toshio Kunikata

Takanobu Higashiyama

Shigeyuki Arai

Shoichi Hamada

Tomohiko Sonoda

An object of the present invention is to provide a crystalline saccharide having novel physical properties, a preparation and uses thereof. The present invention solves the above objects by providing a porous crystalline saccharide having a number of pores, a process for producing the same, comprising the step of keeping hydrous crystalline saccharide at an ambient temperature or higher in an organic solvent for the dehydration, and the use thereof.

Porous crystalline saccharide, its preparation and uses

Objects of the present invention are to provide a novel anhydrous crystalline &#x3b2;-maltose, its preparation and uses. The present invention attains the above objects by providing an anhydrous crystalline &#x3b2;-maltose with a melting point of 154 to 159&#xb0; C.; a process for producing the same, comprising a step of keeping hydrous crystalline &#x3b2;-maltose in an organic solvent at an ambient temperature or higher for the dehydration; and uses of the same.

Anhydrous crystalline &#x3b2;-maltose, its preparation and uses

The object of the present invention is to provide a novel glycosyl derivative of cyclotetrasaccharide represented by cyclo{&#x2192;6)-&#x3b1;-D-glucopyranosyl-(1&#x2192;3)-&#x3b1;-D-glucopyranosyl-(1&#x2192;6)-&#x3b1;-D-glucopyranosyl-(1&#x2192;3)-&#x3b1;-D-glucopyranosyl-(1&#x2192;}, and it is solved by providing a branched cyclotetrasaccharide, wherein one or more hydrogen atoms in the hydroxyl groups of cyclotetrasaccharide are replaced with an optionally substituted glycosyl group, with the proviso that, when only one hydrogen atom in the C-6 hydroxyl group among the above hydrogen atoms is substituted with an optionally-substituted glycosyl group, the substituted glycosyl group is one selected from those excluding D-glucosyl group.

Branched cyclic tetrasaccharide, process for producing the same, and use

The object of the present invention is to provide an &#x3b1;-isomaltosyl-transferring enzyme which forms a cyclotetrasaccharide having the structure of cyclo{&#x2192;6)-&#x3b1;-D-glucopyranosyl-(1&#x2192;3)-&#x3b1;-D-glucopyranosyl-(1&#x2192;6)-&#x3b1;-D-glucopyranosyl-(1&#x2192;3)-&#x3b1;-D-glucopyranosyl-(1&#x2192;} from a saccharide having a glucose polymerization degree of at least three and having both the &#x3b1;-1,6 glucosidic linkage as a linkage at the non-reducing end and the &#x3b1;-1,4 glucosidic linkage other than the linkage at the non-reducing end; microorganisms which produce the enzyme; process for producing the enzyme; cyclotetrasaccharide or saccharide compositions comprising the same; and uses thereof.

&#x3b1;-Isomaltosyltransferase, process for producing the same and use thereof

The present invention has the object to dehydrate hydrous matters without denaturing or deteriorating them by using a dehydrating agent comprising an anhydrous cyclotetrasaccharide, and provides a dehydrating agent comprising the cyclotetrasaccharide; a method for dehydrating hydrous matters through a step of incorporating, contacting or coexisting the cyclotetrasaccharide into, with, or in the hydrous matters; and dehydrated products obtainable thereby.

Dehydrating agent and method for dehydrating moist article using the agent and dehydrated article obtained by the method

A reduction inhibitory agent for active-oxygen eliminating activity comprises trehalose as an effective ingredient. A method for inhibiting the reduction of active-oxygen eliminating activity comprises incorporating either trehalose or the reduction inhibitory agent into plant edible products and/or plant antioxidants. A composition is provided that reduces the active-oxygen eliminating activity of plant edible products and/or plant antioxidants.

Reduction inhibitory agent for active-oxygen eliminating activity

A physiologically active extract comprising an ethyl acetate-soluble ingredient of an indigo plant, which is obtainable by soaking a raw indigo plant in an organic solvent used for extraction. The ethyl acetate-soluble ingredient includes tryptanthrin, 3,5,4&prime;-trihydroxy-6,7-methylenedioxy-flavone, kaempferol, 3,5,7,4&prime;-tetrahydroxy-6-methoxy-flavone, gallic acid, caffeic acid, indirubin, pheophorbide a, and methylpheophorbide a.

Physiologically active extract obtained from indigo plant polygonum tinctorium

Disclosed are a propolis extract where the peculiar odor of propolis is reduced by decreasing the odorizing ingredients, a process to produce the propolis extract which comprises soaking propolis in a hydrophilic organic solvent to effect extraction and treating the liquid layer in the resultant extract with an anion-exchange resin, and a biologically active composition comprising the propolis extract.

Propolis extract

A propolis extract having a reduced peculiar odor is prepared by deceasing the amount of odorizing ingredients. This propolis extract can be used to prepare biologically active compositions.

A propolis extract which is prepared by adjusting the pH of propolis to 5.5-7.0 to improve the water-solubility of the effective ingredients of propolis, a composition containing the propolis extract, and a method for improving the water-solubility of propolis extracts.

Propolis extract with improved water-solubility

A saccharide composition comprising maltooligosyl derivatives of turanose and palatinose which can be readily produced, separated, and purified in a relatively-high yield from maltooligosylsucrose by allowing non-reducing saccharide-forming enzymes to act on aqueous solutions containing maltooligosylsucrose. These saccharides are reducing oligosaccharides with a mild and high-quality sweetness and can be used orally and parenterally, as well as being readily metabolized and used by living bodies.

Saccharide composition comprising maltooligosylturanose and

Disclosed is a novel non-reducing oligosaccharide with neotrehalose structure represented by the general formula as shown by: ##STR1## The oligosaccharide is obtainable by exposing an aqueous solution containing neotrehalose to a saccharide-transferring enzyme, and has a superior stability, reduced sweetness, appropriate viscosity, no susceptibility to crystallization and less fermentability. These features make it very useful in various compositions including foods, beverages, cosmetics and pharmaceuticals.

Non-reducing oligosaccharide with neotrehalose structure, and its

A separation system to prepare a high .alpha.-glycosyl-L-ascorbic acid content product involves the use of a specific anion-exchange membrane having a molecular weight cut-off in the range of about 100-1,000. The system readily separates .alpha.-glycosyl-L-ascorbic acid from L-ascorbic acid and other impurities and provides a relatively-high yield.

Separation system for preparing high .alpha.-glycosyl-L-ascorbic acid

A hair restorer which comprises a carrier and an effective amount of one or more compounds selected from the group consisting of 3-[4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl]-2-propenoic acid, benzenepropanoic acid 4-(2-carboxyethenyl)-2-(3-methyl-2-butenyl)phenylester, and their salts, in the treatment and prevention of alopecia.

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Okayama, Japan

Hajime Aga