Chinese Academy of Sciences

Vigonvita Life Sciences Co., Ltd.

Shanghai Institute of Materia Medica, Chines Academy of Sciences

Haji Akber Aisa

Hualiang Jiang

Yang He

Jingshan Shen

Leike Zhang

Gengfu Xiao

Yuanchao Xie

Guangying Sun

Guliqire Adili

Munire Abuduaini

Yongxin Zhao

A method for preparing high-purity granatin A: by means of a combination of low-temperature liquid phase chromatography and an isomerization conversion purification method, using pomegranate peel extract as a source material, granatin A of over 98% purity can be acquired, and can be used as a standard product for quality control of pomegranate peel, pomegranate flower, or other medicinal material with granatin A as the active ingredient.

Preparation method for high-purity granatin A

The present invention relates to an antiviral application of nucleoside analogs. Specifically, the present invention relates to uses of nucleoside analogs and a pharmaceutical composition thereof as: (a) inhibitors for inhibiting the replication of coronaviruses, influenza viruses, respiratory syncytial viruses, flaviviridae viruses, filoviridae viruses and/or porcine epidemic diarrhea virus (PEDV); and/or (b) medicines for treating and/or preventing and mitigating diseases caused by coronavirus, influenza virus, respiratory syncytial virus, flaviviridae virus, filoviridae virus and/or porcine epidemic diarrhea virus (PEDV) infections. The nucleoside analogs according to the invention may treat and/or prevent and mitigate respiratory infection, pneumonia (COVID-19) and other related diseases caused by 2019 novel coronavirus infection.

Antiviral application of nucleoside analog or combination formulation containing nucleoside analog

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Xinjiang, China

Haji Akber Aisa