Reata Pharmaceuticals, Inc.

Haizhou Sun

Xin Jiang

Melean Visnick

Christopher F Bender

Eric Anderson

Xiaofeng Liu

Ha Do

Disclosed herein are compounds of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders, including those associated with inflammation and cancer.

C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof

Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided. 

A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof

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Irving, TX, United States of America

Haizhou Sun