Purdue Pharma L.p.

Purdue Pharmaceuticals L.p.

Other

The P.f. Laboratories, Inc.

Haiyong Hugh Huang

Richard O Mannion

Edward P O'Donnell

William H McKenna

Debora Guido

Manjunath S Shet

William Henry Mckenna

Richard Owen Mannion

William Henry McKenna

Edward Patrick O'Donnell

Edward Patrick O'donnell

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

Tamper resistant dosage forms

The present invention relates to a solid oral extended release pharmaceutical dosage form comprising a cured extended release matrix formulation, the extended release matrix formulation comprising:

Abuse deterrent morphine sulfate dosage forms

In certain embodiments, the present invention is directed to a solid controlled release dosage form comprising: a core comprising a first portion of an opioid analgesic dispersed in a first matrix material; and a shell encasing the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material; wherein the amount of opioid analgesic released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37 C.

Encased tamper resistant controlled release dosage forms

Disclosed in certain embodiments is a pharmaceutical formulation (e.g., parenteral formulation) comprising a therapeutically effective amount of nalmefene or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable adjuvant (e.g., parenterally acceptable adjuvant) that promotes the rate at which the nalmefene or salt thereof is more rapidly absorbed into the systemic circulation of a subject identified as in need thereof.

Compositions and methods for opioid antagonist delivery

Disclosed in certain embodiments is a solid oral dosage form comprising a heat-labile gelling agent; a thermal stabilizer; and a drug susceptible to abuse.

Tamper resistant pharmaceutical formulations

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Princeton, NJ, United States of America

Haiyong Hugh Huang