Lawrence Livermore National Security, LLC

Haiyin Chen

Satinderpall Singh Pannu

Angela C Tooker

Vanessa M Tolosa

Fang Qian

Elizabeth K Wheeler

Heeral J Sheth

Kris Kulp

Margaret Windy McNerney

Bryan D Hudson

In one embodiment, a system includes a bioreactor coupled to a substrate. The bioreactor includes: a plurality of walls defining a reservoir; a plurality of fluidic channels in at least some of the walls; a fluidic inlet in fluidic communication with the reservoir via, the fluidic channels; a fluidic outlet in fluidic communication with the reservoir via the fluidic channels; and one or more sensors coupled to the reservoir, each sensor being configured to detect one or more of: environmental conditions in the reservoir; and physiological conditions of one or more cells optionally present in the reservoir. In another embodiment, a method includes delivering media to a reservoir of a bioreactor; delivering a plurality of cells to the reservoir, controlling a reservoir temperature and a reservoir gas composition; using one or more of the sensors to monitor environmental and physiological conditions; and reporting the environmental and/or physiological conditions.

Miniaturized, automated in-vitro tissue bioreactor

Growing community of inventors

San Ramon, CA, United States of America

Haiyin Chen