Chinese Academy of Sciences

East China University of Science and Technology

Haiyan Xu

Fajun Nan

Min Li

Yangming Zhang

Zhaobing Gao

Haining Hu

Huanan Liu

Xiaoping Pi

Jing Lan Chen

Sheng Liu

Xiliang Zhang

Fei Chen

Fei Shen

Jianfeng Huang

Liang Fang

Shengying Qian

Chifei Wu

Xuanquan Zhou

Weihong Guo

Guozhang Wu

Xianhui Li

Na Yu

Li Lang

Qiuying Zhang

Jingjie Han

Pingzheng Zhou

The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window. 

KCNQ potassium channel agonist, and preparation method therefor and use thereof

KCNQ potassium channel agonists, method of preparation and method of use thereof

The present invention provides compounds having the structure represented by general formula I, pharmaceutically acceptable salts thereofagonist, preparation methods therefor and a use thereof in the preparation of a medicine for the treatment of nervous system diseases. The compounds or pharmaceutical compositions thereof can be used as the KCNQ potassium channel agonist for treating nervous system diseases. Compared to retigabine, a compound in the prior art, the compound of the present invention have the same or better therapeutic effect, are easier for synthesis and storage, and less prone to oxidate deterioration. 

Compound as KCNQ potassium channel agonist, preparation method therefor and use thereof

The present invention discloses a nanophase carbon black grafted with organic compounds, comprising (a) a first component: 100 parts by weight of original carbon black particles, and (b) a second component: 5-300 parts by weight of grafting organic compounds having or producing free radicals which is grafted onto the surface of the carbon black, wherein the molecular weight of the grafting organic compounds is 100-10000, and the nanophase carbon black has a particle size of 1-100 nm. The invention also discloses the synthesis thereof and articles therefrom.

Nanophase carbon black grafted with organic compound in situ

Growing community of inventors

Shanghai, China

Haiyan Xu