Zhengzhou University

Zhengzho University

Suzhou Lingxi Biotechnology Co., Ltd.

Haiwei Xu

Guifu Dai

Di Wu

Hongmin Liu

Xiaopei Zhang

Zhenwei Wu

Yanan Wang

Jing Zhao

Zhenzhen Guan

Ning Shang

Jian Wu

Fengjuan Wu

Huanfei Liu

Jin Zhao

Songlin Zhu

Dan Zhao

Pengpeng Shen

Zibo Fu

Wei Han

Jiazhen Zhu

Mengjiao Liu

Hang Wang

Shuqiu Zhang

Zhiwen Jiang

Liping Zhu

Guangming Yan

Lijun Yan

Weiyi Li

Ruijing Dong

Yake Wang

Na Gao

Shufeng Li

Hailing Qiao

Yan Fang

Qiang Wen

A method of treatment or prevention of fibrosis of human tissue or organ. The method includes administering a patient in need thereof a compound of formula (I).

Andrographolide derivatives and method of using the same for treatment or prevention of fibrosis

A compound represented by formula I or II. Rand Rare at each occurrence selected from the group consisting of hydrogen, methyl, phenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 2-fluorophenyl, 2-chlorophenyl, 2-bromophenyl, 3-fluorophenyl, 3-chlorophenyl, 3-bromophenyl, 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 2-fluoro-3-methoxyphenyl, 3-methoxy-4-chlorophenyl, 2,4-difluorophenyl, 2,4-dichlorophenyl, 2,4-dibromophenyl, 2-fluoro-4-chlorophenyl, 2-bromo-4-chlorophenyl, 3-fluoro-4-chlorophenyl, 3-bromo-4-chlorophenyl, 3,4-difluorophenyl, 3,4-dichlorophenyl, 3,4-dibromophenyl, 2-chloro-4-fluorophenyl, 2-bromo-4-fluorophenyl, 3-chloro-4-fluorophenyl, 3-bromo-4-fluorophenyl, 2-fluoro-4-bromophenyl, 2-chloro-4-bromobenzene group, 3-fluoro-4-bromophenyl, 3-chloro-4-bromophenyl, 2,3,4-trichlorophenyl, 2-methoxy-4-chlorophenyl, 2-hydroxy-4-chlorophenyl, 2-hydroxy-4-methoxyphenyl, 3-fluoro-4-(4-methylpiperazinyl)phenyl, 4-(N,N-dimethylamino)phenyl, and 3-fluoro-4-(4-morpholinyl)phenyl. Rand Rare hydrogen, or Rand Rare at each occurrence selected from the group consisting of &#x2014;CHCHCOOH, &#x2014;CHCHCHCHCOOH, &#x2014;CHCH&#x2550;CHCHCOOH, and &#x2014;CHCHCHCHCHCHCHCOOH; or Rand Rare &#x2014;COR, and Ris selected from the group consisting of 3-pyridyl, &#x2014;CHCHCOOH, &#x2014;CHCHCHCHCOOH, &#x2014;CHCH&#x2550;CHCHCOOH, and &#x2014;CHCHCHCHCHCHCHCOOH.

Andrographolide compound and method for treatment or prevention of fibrotic disease using the same

Disclosed is use of andrographolide derivative as shown by general formula 1 in manufacture of medicaments for anti-hepatitis C virus, and preventing and treating immunological liver damage caused by virus infection and different chemical liver damage. 

Use of 15-benzylidence-14-deoxy-11, 12 -dehyroandrographolide derivative in manufacture of medicaments for protecting liver and anti-hepatitis C virus

Use of 15-benzylidene-14-deoxy-11, 12-dehydroandrographolide derivative in manufacture of medicaments for protecting liver and anti-hepatitis C virus

The present invention relates to the preparation of anti-tumor drugs with andrographolide derivatives, which belongs to the field of pharmaceutical technology, and involves 15-benzylidene substituted derivatives of 14-deoxy-11,12-didehydro-andrographolide and their 3,19-ester derivatives. Proved by the experiments, these compounds significantly inhibited the colony formation and migration ability of various cancer cells, and also inhibited the migration ability of vascular endothelial cells in vitro. The compounds of this invention significantly inhibited the tumor growth, invasion, metastasis and angiogenesis on mouse xenograft models, and inhibited the experimental lung metastasis of B16-F10 malignant melanoma cells. Therefore, this class of compounds could be used as the active ingredients for the preparation of antineoplastic drugs, which are of efficiency and low-toxicity. Thereby it has potential to expand the selectable range of clinical drug and is of high significance to make full use of the plant resources of

Uses of 15-benzylidene-14-deoxy-11,12-didehydroandrographolide derivatives in the preparation of antineoplastic drugs

Growing community of inventors

Zhengzhou, China

Haiwei Xu