Sunovion Pharmaceuticals Inc.

Sumitomo Pharma America, Inc.

Haitao Zhang

Harold Scott Wilkinson

John R Snoonian

Robert Joseph Prytko

Shahla Jamzad

Andrea Bauer

Michael Joseph Sizensky

Xiaoxia Chen

Nandkumar Nivritti Bhogle

Kostas Saranteas

Takahiko Hashizuka

Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.

Salts, crystal forms, and production methods thereof

The various aspects present inventions provide various crystalline forms of (S)-(&#x2212;)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.

Crystal forms and production methods thereof

The present disclosure relates to salts of (R)-1-(8-fluoroisochroman-1-yl)-N-methylmethanamine, crystalline forms thereof, and methods of preparation thereof, which are useful in the treatment of CNS disorders.

Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof

Growing community of inventors

Shrewsbury, MA, United States of America

Haitao Zhang