Novo Nordisk A/s

Haisun Zhu

Henrik Oestergaard

Jianhe Chen

Laust Bruun Johnsen

Prafull S Gandhi

Rong Zhou

Per J Greisen

Karina Thorn

Mikkel Nors Harndahl

Bjarne Gram Hansen

Morten Groenbech Rasch

Zhiru Yang

Anders Svensson

Eva Johansson

The present invention relates to improved procoagulant antibodies including bispecific antibodies capable of binding to coagulation Factor IX (FIX) or the activated form thereof Factor IXa (FIXa) and optionally Factor X (FX) and the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A.

Procoagulant antibodies

The present invention relates to multispecific procoagulant antibodies capable of binding to coagulation Factor IX (FIX) and/or the activated form thereof Factor IXa (FIXa), and Factor X (FX) and/or the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes or parts thereof and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A as well as kits, methods of manufacture and methods of use.

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Norfolk, MA, United States of America

Haisun Zhu