University of Toronto

The University of Western Ontario

ShanghaiTech University

Haiming Huang

Sachdev Singh Sidhu

Guohua Pan

Shun-Cheng Li

Shane Miersch

Tomonori Kaneko

Donghui Wu

Shusu Liu

Xuan Cao

Sachedv S Sidhu

Provided are antibodies or fragments thereof having binding specificity to anti-IL-18 receptor alpha or beta. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and inflammatory and autoimmune diseases are also provided.

Human antibodies to human interleukin 18 receptor alpha or beta

The present invention relates to variant SH2 domains for binding a phosphotyrosine (pTyr)-containing peptide. The variant SH2 domains of the present invention include a parent SH2 domain having at least one amino acid substitution in a pre-defined region of 15 amino acid positions of the parent SR2 domain, wherein said at least one amino acid substitution increases the affinity of the variant SH2 domain for the pTyr-containing peptide relative to the parent SH2 domain. The present application relates also to methods of using the variant SH2 domains in the treatment of protein kinase-associated disorders, or the diagnosis or prognosis of protein kinase-associated disorders, for isolating and measuring the concentration of pTyr-containing molecules, and as reagents in research.

SH2 domain variants

Growing community of inventors

Toronto, Canada

Haiming Huang