Shandong Branden Medical Device Co., Ltd

Saraya Co., Ltd.

Shandong Rientech Medical Technology Co., Ltd

Shangdong Intech Medical Technology Co., Ltd

Haijun Zhang

Chao Zhou

Cuihai Duan

Liming Liu

Shoutao Lu

Guang Liu

Yuxia Yin

Wenrui Cao

Wenbo Hou

Tomomasa Itarashiki

Kunshan Yuan

Daiki Anraku

Hairong Xu

Qinghai Zhao

Rumeng Wang

Jianglong Yu

Min Yang

Junbo Ge

Shenguo Wang

Jianzhong Bei

Xiangfei Wang

Xiaoxin Shang

Maoquan Li

Haihong Guo

Guoqiang Qu

Shudi Zhi

The present disclosure relates to a medical silicon rubber having high mechanical property and a preparation method thereof. The medical silicon rubber comprises the following raw materials in parts by weight: 50˜90 parts of silicon rubber, 10˜50 parts of polyurethane, 10˜50 parts of fillers, 2˜6 parts of hydrogen-containing silicon oil and 2˜5 parts of a vulcanizing agent. The preparation method comprises: evenly mixing a part of fillers with silicon rubber in an internal mixer, and evenly mixing the other part of fillers with polyurethane in the internal mixer; and mixing the mixed polyurethane on an open type rubber refining machine, then successively adding hydrogen-containing silicon oil, the evenly mixed silicon rubber and the vulcanizing agent into the open type rubber refining machine many times by small portions, and finally vulcanizing the mixed rubber on a plate rubber vulcanizing machine for 5˜15 min at 150˜190° C.

Medical silicon rubber having high mechanical property and preparation method thereof

A blood regurgitation preventing puncture and guidance device without skin dilation is provided. The puncture and guidance device mainly includes a needle tube, a dilation tube, a sheath, and a deceleration and stop device. A hydrophilic ultrasound developing coating is provided on a surface of the sheath to lay a foundation for visual puncture. The sheath and the dilation tube contain X-ray developing particles, and are provided with a transition section.

Blood regurgitation preventing puncture and guidance device without skin dilation

A sterilization apparatus includes a sterilization chamber, a vaporization chamber, a wall partitioning the vaporization chamber into a first chamber and a second chamber, a first passage connecting the first chamber and the second chamber, a table arranged in the first chamber, a nozzle arranged toward the table to spray a sterilizing agent toward the table, a liquid reservoir for storing the liquid component of the sterilizing agent sprayed toward the table, a second passage connecting the second chamber and the sterilization chamber, and a means for decompressing the sterilization chamber and also decompressing the first chamber and the second chamber of the vaporization chamber through the first passage and the second passage, wherein the first passage is formed by a belt-shaped gap having a small thickness and a large width.

Sterilization method and sterilization device

The disclosure provides a medical sealant glue capable of promoting wound healing and a preparation method thereof. The medical sealant glue is formed by covalent cross-linking of two components after being physically mixed by a mixing tool, wherein the first component is a nucleophilic component, and the second component is an electrophilic component. The medical sealant glue has a gelation time of 1-10 s, a swelling ratio of 0-100%, a bursting strength of 100-250 mmHg, and a degradation time of 0.5-300 days. The nucleophilic component of the medical sealant glue contains exosome or hyaluronic acid and chitosan, and thus the medical sealant glue not only has the effect of promoting wound healing, but also has antibacterial and anti-infection effects.

Medical sealant glue capable of promoting wound healing and preparation method thereof

A porous bionic skull repairing material includes a polymer material, whose structure is consistent with that of a human skull. The surface layers of the porous bionic skull repairing material are dense layers which are composed of non-degradable or degradable polymer materials and has blind holes having an asymmetric structure, and the inner layer of the porous bionic skull repairing material is a loose layer which has a porous structure. The repairing material can be molded by adopting a mixed mould pressing method or a 3D printing method, simulates a bone structure, with two dense sides and a loose middle, of a human skull to the greatest extent.

Porous bionic skull repairing material, preparation method and implement method thereof

A method for preparing a degradable drug-loaded microsphere for embolization and a product obtained therefrom, includes the steps of: dissolving a degradable material in an organic solvent, then adding a drug and mixing well to form a suspension or solution; then pouring the drug-containing suspension or solution into an aqueous solution of polyvinyl alcohol, stirring, and thereafter adding water twice for dilution, to prepare the degradable drug-loaded microsphere. The microsphere prepared by the present invention has the advantages of having a controllable particle size, a high drug loading capacity, and a regular spherical shape, being convenient for sieve sizing and accurate particle-size indication, and being accurately targeted to an embolized blood vessel, and the like, and thus has a good application prospect in interventional embolization therapy.

Method for preparing degradable drug-loaded microsphere for embolization, and product obtained therefrom

Provided is a system for supplying a liquid (such as an irritative chemical solution) safely. This liquid supplying system comprises: (a) a means that creates a negative pressure in a treatment chamber by driving a first depressurizing means and depressurizing the treatment chamber; (b) a means that introduces the negative pressure of the treatment chamber to a measurement chamber; (c) a means that maintains the negative pressure introduced to the measurement chamber; (d) a means that sucks a liquid from a container into the measurement chamber by employing the negative pressure of the measurement chamber; and (e) a means that sucks the liquid of the measurement chamber into the treatment chamber by employing a vacuum in the treatment chamber.

Liquid supplying system and method for driving same

Provided is a system for supplying a liquid (such as an irritant chemical solution) safely. This liquid supplying system comprises: a base on which a container containing liquid is placed; a hollow needle having a spired part; a first movement mechanism that moves the needle between a first needle position at which the spired part is separated from the container and a second needle position at which the spired part is passed through a wall of the container; a hollow tube having a smaller outer diameter than the inner diameter of the lumen of the needle; and a second movement mechanism that moves the tube between a first tube position separated from the container and a second tube position at which the tube is passed through the lumen of the needle located at the second needle position and is inserted inside the container.

Liquid supplying system

A coronary stent is provided with asymmetric drug releasing controlled coating used in interventional therapy of coronary disease, containing a bare stent and a coating consisting of drug and carrier, the coating is coated onto the outer wall surface of the bare stent, and is multi-layered. The drug concentration in the coating increases in sequence from the outer layer to the inner layer. The drugs used in different layers of the coating may be identical or different, and particularly may be one or more selected from taxol, rapamycin, heparin, docetaxel and a combination thereof. The carrier may be a random (lactide-glycolide) copolymer having a molecular weight of 50,000-200,000. The drug-coated stent of the present invention employs highly effective drugs, enabling a thinnest coating and reducing the vascular irritation. The drug release is regulated by altering the coating manner so as to satisfy the clinical requirement for controlled drug release. The employed asymmetric coating promotes regenerative repairing of vascular endothelium. The present invention is a drug-coated coronary stent with reasonable design, with the coating capable of effectively preventing vascular restenosis and reducing occurrence of late thrombosis.

Coronary stent with asymmetric drug releasing controlled coating

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Shandong, China

Haijun Zhang