Global Alliance for Tb Drug Development

Astar Biotech LLC

Chinese Academy of Sciences

Chinese Academy of Medical Sciences

Haihong Huang

Dongfeng Zhang

Peng Li

Christopher Blair Cooper

Chunrong Yu

Yang Liu

Hao Zhang

Kai Liu

Takushi Kaneko

Zhenkun Ma

Gang Zhang

Nader Fotouhi

Yu He

Chun Li

Wenjie Wang

Jun Wei

Dali Yin

Jingbin Wang

Hongyi Zhao

Binna Liu

Liya Zhu

Ziyun Lin

Liyuan Mou

Zhengui Nie

Xueyu Ouyang

Shanying Peng

The present invention discloses a nitrogen-containing heterocyclic substituted benzoxazine oxazolidinone compound, a preparation method and use thereof in the manufacture of a medicament for treating and/or preventing infectious diseases caused by. Specifically, the present invention relates to a compound represented by formula (I) and stereoisomer thereof, pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the compounds of the present invention, use thereof, a method for preparing the compound, in which X, X, Rand Rare described in the specification.

Nitrogen containing heterocycle substituted benzoxazine oxazolidinone compound and preparation method and use thereof

The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treatingand other microbial infections, either alone or in combination with other anti-infective treatments. 

Substituted phenyloxazolidinones for antimicrobial therapy

The present invention relates to compounds of Formula VIII with absolute configuration R or S: as well as pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein the variables are described herein. The present invention further relates to pharmaceutical compositions which comprise the compounds of Formula VIII, and to methods for inhibiting protein kinase and methods of treating diseases, such as cancers, inflammation.

Protein kinase inhibitors

The present invention relates to compounds of Formula I: as well as pharmaceutically acceptable salts, hydrates, isomers, or solvates thereof, wherein the variables are described herein. The present invention further relates to pharmaceutical compositions which comprise the compounds of Formula I, and to methods for inhibiting protein kinase and methods of treating diseases, such as cancers, inflammation.

The present invention relates to riminophenazines having heteroaromatic substitutions, including those with 2-heteroaryl-amino substituents, to their preparation, and to their use as drugs for treatingand other microbial infections, either alone or in combination with other anti-infective treatments. A general representation of the 2-(heteroaryl)amino-riminophenazines is shown below. 

Riminophenazines with 2-(heteroaryl)amino substituents and their anti-microbial activity

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Beijing, China

Haihong Huang