Hangzhou Dac Biotech Co., Ltd.

Alibaba Group Holding Limited

Suzhou M-conji Biotech Co., Ltd

Haifeng Zhu

Qingliang Yang

Huihui Guo

Hangbo Ye

Yuanyuan Huang

Shun Gai

Junxiang Jia

Hongsheng Xie

Xiaomai Zhou

Linyao Zhao

Qianqian Tong

Minjun Cao

Chengyu Yang

Zhixiang Guo

Yifang Xu

Yongxin Robert Zhao

Lu Bai

Chen Li

Shuihong Gao

Yanlei Yang

Chunyan Wang

Zhichang Ye

Robert Yongxin Zhao

Wenjun Li

Liang Ye

Yuejun Hu

Zhicang Ye

Chen Lin

Xiaotao Zuo

Jun Xu

Xiang Cai

Minjun Chao

Qingyu Su

Jie Peng

The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.

Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers

An example information query method including receiving a query parameter including keyword information and one or more pieces of language feature information; generating one or more query request strings corresponding to the one or more pieces of language feature information respectively according to the keyword information; determining corresponding position intervals of the one or more pieces of language feature information in a second index according to a pre-established first index, the first index including a mapping relationship between the language feature information and the position intervals of the second index, the second index including a mapping relationship between keywords and information pages; and acquiring query results corresponding to the one or more query request strings respectively according to the determined corresponding position intervals of the one or more pieces of language feature information in the second index. The techniques of the present disclosure reduce the cost of multi-language query.

Information query

Growing community of inventors

Hangzhou, China

Haifeng Zhu