Other

Astellas Pharma Gmbh

Shanghai Institute of Pharmaceutical Industry

National Food Research Institute

China State Institute of Pharmaceutical Industry

Haifeng Hu

Bin Zhou

Jun Lin

Quanhai Liu

Kozo Ochi

Hideyuki Muramatsu

Yongzhi Shu

Motohiro Hino

Akihiko Fujie

Baoquan Zhu

Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity. 

Platinum (II) compound, preparation method therefor, and pharmaceutical composition and application thereof

This invention relates to a method for increasing the productivity of the secondary metabolite in a micro-organism, for example, the improvement of antibiotic producers by conferring drug-resistant mutations to micro-organisms.

Method for increasing productivity of secondary metabolite by conferring drug-resistant mutations

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Shanghai, China

Haifeng Hu