Chinese Academy of Agricultural Sciences

Haifei Liang

Sanwen Huang

Ran Du

Qinggang Liao

Junbo Gou

Jianbin Yan

Chong Li

Xingyao Xiong

Provided are a taxadiene synthase TcTS2, an encoding nucleotide sequence and use thereof. The amino acid sequence of TcTS2 includes or consists of: (a) an amino acid sequence represented by SEQ ID NO: 1; or (b) a functional homologous sequence having at least 80% sequence similarity with the amino acid sequence represented by SEQ ID NO: 1; or (c) an amino acid sequence having TcTS2 activity with addition, deletion, or substitution of one or more amino acids in the amino acid sequence represented by SEQ ID NO: 1. TcTS2 and the nucleotide sequence encoding the TcTS2 provide new gene resources for improving the yield of taxol, and they may be used for modifying chassis hosts by plant genetic engineering and metabolic engineering strategies to produce taxol and the intermediates thereof etc., thereby having significant economic and social value.

Taxadiene synthase TcTS2, encoding nucleotide sequence and use thereof

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Shenzhen, China

Haifei Liang