Hoboomlife Bio-technology (shenzhen) Co., Ltd.

Huawei Technologies Co., Limited

Tencent Technology (shenzhen) Company Limited

Haichao Zhang

Jiansheng Chen

Liqing Zhao

Zhigang Duan

Beijia Huang

Ying Xiong

Tianyu Wang

Yongliang Huang

Chuan Lv

Zidong Mo

Xiangya Feng

Zhi Xiao

The present disclosure provides an innovative method for improving the enzyme activity of an NMN biosynthetic enzyme Nampt, and relates to the technical field of genetic engineering. A mutant protein of the present disclosure is obtained by firstly analyzing a target protein Nampt using two softwares FoldX and DeepDDG, and then predicting multiple key sites influencing the enzyme functions and finally performing the semi-rational design of the enzyme. In the examples of the present disclosure, 10 mutant strains are constructed using the designed primers according to the principle of point mutation, and 8 of the mutants have higher activity than a wild-type strain, in which the NMN yield of the mutant Nampt-V365L is increased by 62%, and the NMN yields of the mutants Nampt-S248A, Nampt-N164L, Nampt-S382M, Nampt-A245T and Nampt-A208G are increased by 34%, 27%, 27%, 22% and 17% respectively.

Innovative method for improving enzyme activity of NMN biosynthetic enzyme nampt

Innovative method for improving enzyme activity of NMN biosynthetic enzyme Nampt

A method for displaying a skin of a virtual character includes: displaying a matchmaking user interface (UI) for matching k user accounts online for gaming in the same virtual world, k being a positive integer; obtaining a customization parameter of a customized skin model of a target virtual character from a server when the target virtual character is present in virtual characters used by the k user accounts; loading n target skin component materials of the customized skin model according to the customization parameter, n being a positive integer; and displaying a gaming UI. The customized skin model is one of complete skin set models corresponding to the target virtual character and includes n skin components in a same style. The gaming UI includes the target virtual character located in the virtual world, the target virtual character wearing the customized skin model.

Method, apparatus, and device for displaying skin of virtual character

The present disclosure relates to electrostatic protection terminals. One example terminal includes a target interface, a protected circuit, a protection unit, a switch unit, and a switch control unit. The protected circuit is configured to suppress an electrostatic discharge (ESD) current or an electrical overstress (EOS) current. A first end of the protection unit is electrically connected to a first pin of the target interface. A second end of the protection unit is electrically connected to a second pin of the protected circuit. The first pin is any pin of the target interface. The second pin is a pin that is in the protected circuit and that needs to be electrically connected to the first pin. The switch unit is connected to the protection unit in parallel. The switch control unit is configured to control the switch unit to be open or closed.

Electrostatic protection circuit

Growing community of inventors

Shenzhen, China

Haichao Zhang