Genomatica, Inc.

Constellation Brands, Inc.

Reg Life Sciences, LLC

Haibo Wang

Andreas W Schirmer

Zhihao Hu

Stephen B Del Cardayre

Myong K Ko

Baolong Zhu

Louis G Hom

Vikranth Arlagadda

Elizabeth J Clarke

Emanuela E Popova

Noah Helman

Cindy Chang

Alma Itzel Ramos-Solis

Anil Jageshwar Shrikhande

Steve Anthony Kupina

Simon Li

Perry Y Liao

Anil J Shrikhande

Patricia J Cole

Risha Lindig Bond

Steve A Kupina

Elizabeth Clarke

The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and derivatives thereof which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc.

1,3-fatty diol compounds and derivatives thereof

The present disclosure relates to chemo-enzymatic processes for the preparation of lactones (including, e.g., macrolactones, γ-lactones, and δ-lactones) and/or macrocyclic ketones, which are compounds of industrial value, for example, for use as fragrance ingredients. The chemo-enzymatic processes combine the in vivo microbial production of fatty acid derivatives and the subsequent ex vivo synthetic transformation of the fatty acid derivatives to provide the lactones and macrocyclic ketones.

Semisynthetic routes to organic compounds

The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

Methods of producing omega-hydroxylated fatty acid derivatives

The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.

Microbial production of fatty diols

The disclosure relates to downstream processing of fatty alcohol (FALC) and provides a novel purification method that provides FALC at high purity and yield.

Downstream processing of fatty alcohol compositions produced by recombinant host cells

The present disclosure relates to processes that combine microbial production of organic intermediates and subsequent synthetic transformation to provide compounds of industrial value, including compounds used in fragrances.

Chemo-enzymatic process

The present invention relates to a novel grape extract, and processes for making such, that is useful for, inter alia, treating pre-hypertension, Metabolic Syndrome and/or the conditions that comprise Metabolic Syndrome. The processes of the present invention produce a highly concentrated polyphenol product by maximizing extraction of monomeric and oligomeric procyanidins and minimizing extraction of polymeric procyanidins. The grape extract of the present invention comprises between about 5-15% monomers, about 5-20% dimers, about 3-10% trimers, about 2-10% tetramers, and about 2-10% pentamers by weight. The grape extract of the present invention can be formulated into dietary supplements, including capsules, tablets, powders, solutions, gels, suspensions, creams, gels, and the like. These dietary supplements in, for instance, powder or solution form, may be added to nutraceuticals, foods and/or beverages to form functional nutraceutical, food, and/or beverage products.

Grape extract, dietary supplement thereof, and processes therefor

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South San Francisco, CA, United States of America

Haibo Wang