The University of North Carolina at Chapel Hill

Haibao Jin

Mark H Schoenfisch

Lei Yang

Mona Jasmine R Ahonen

Evan Scott Feura

Sara Elizabeth Maloney

Several embodiments of hyperbranched structures are disclosed. In some embodiments, the hyperbranched structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and also to the use of hyperbranched structures. The covalently modified hyperbranched structures may be tailored to release nitric oxide in a controlled manner and are useful for eradication of both gram positive and gram negative bacteria as well as other microbes.

Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto

Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions.

Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto

Disclosed herein are cyclodextrin molecules covalently modified to store and release nitric oxide, as well as methods of making and uses thereof. The covalently modified cyclodextrin molecules may be tailored, in several embodiments, to release nitric oxide in a controlled manner and are useful for reduction and/or eradication of bacteria and for the treatment of disease.

Growing community of inventors

Carrboro, NC, United States of America

Haibao Jin