Gilead Sciences, Inc.

General Electric Company

Hai Yang

David Sperandio

Dustin S Siegel

Hon Chung Hui

Richard L Mackman

Jay P Parrish

Michael Sangi

Gregory F Chin

Michael R Mish

Britton Kenneth Corkey

Constantine G Boojamra

Kerim Babaoglu

Robert H Jiang

Oliver L Saunders

Michael O Clarke

Bindu Goyal

Kristyna M Elbel

Eugene J Eisenberg

Jeff A Zablocki

Jinfa Du

Tetsuya Kobayashi

Petr Jansa

Samuel E Metobo

Mark J Bartlett

Ruben Martinez

Evangelos Aktoudianakis

Jennifer Leigh Cosman

Rick Andrew Lee

Manuel Munoz

John R Barber

Lianhong Xu

Scott D Schroeder

Dmitry Koltun

Eric Q Parkhill

Suet Chung Yeung

Ryan McFadden

Julian Andrew Codelli

Caibin Xiao

Joshua J Van Veldhuizen

Nathan D Shapiro

Yunfeng Eric Hu

Xiaochun Han

Jennifer Alissa Loyer-Drew

Doris T Tang

Michael O' Neil Hanrahan Clarke

Caroline Chihyu Sui

Sophie Shevick

Jianhua Fang

Russell James Macdonald

Deeba Ensan

Stephen Ho

Dustin Siegel

Kyle C Tamshen

Tim Hansen

Wei Lu

Su Lu

Michael Mish

Kristyna Elbel

Rick Lee

Zhigang Deng

Xin Gao

John H Barber

Zijun Xia

Gregory Chin

Jeff Zablocki

Liping Zheng

Linglu Yang

The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

Antiviral compounds

The present disclosure provides pyrimidine dione compounds of Formula I

CD73 compounds

Provided herein is A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

Imidazopyrimidine derivatives

Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Compounds and methods for antiviral treatment

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R, R, R, R, R, R, R, and Rare described herein.

Benzimidazole derivatives as bromodomain inhibitors

The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

Pyrazolo[1,5-A]pyrimidines for antiviral treatment

The present disclosure provides indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors of Formula I: or pharmaceutically acceptable salts thereof, in which X, L, n, m, R, R, R, R, R, and Rare as defined herein, as well as pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using the same to treat conditions mediated by IDO1.

Benzimidazole and imadazopyridine carboximidamide compounds

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R, R, R, R, R, and X are described herein.

Benzimidazolone derivatives as bromodomain inhibitors

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula I wherein R, R, R, R, R, W, X, and Z are as described herein.

Quinoline derivatives as bromodomain inhibitors

The present invention relates to anti-RSV compounds of Formula (I) and methods for use of the compounds in the treatment and prevention of RSV infection. 

Anti-RSV compounds

Growing community of inventors

San Mateo, CA, United States of America

Hai Yang