Gilead Pharmasset LLC

Gilead Sciences, Inc.

Hai-Ren Zhang

Michael Joseph Sofia

Ganapati Reddy Pamulapati

Bruce Ross

Suguna Rachakonda

Byoung-Kwon Chun

Peiyuan Wang

Bruce S Ross

Wonsuk Chang

Dhanapalan Nagarathnam

Jinfa Du

Dhanpalan Nagarathnam

Devan Naduthambi

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.

Nucleoside phosphoramidates

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.

A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.

Synthesis of purine nucleosides

Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing the same.

Stereoselective synthesis of phosphorus containing actives

Disclosed herein is a compound represented by formula 1 or its hydrate thereof in crystalline or crystal-like form. 

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San Jose, CA, United States of America

Hai-Ren Zhang