Johns Hopkins University

Other

Guilford Pharmaceuticals, Inc.

Boston Scientific Scimed, Inc.

Université Pierre Et Marie Curie (paris Vi)

Arteriocyte Inc.

Johns Hopkins Singapore Pte Ltd.

Hai-Quan Mao

Kam W Leong

Zhong Zhao

James Perry English

Sashank Reddy

Xiaowei Li

Russell E Martin

Wenbin Dang

Justin Sacks

David Peter Nowotnik

Gerald Brandacher

Jose Luis Santos

Xuesong Jiang

Shuming Zhang

Russell Martin

Yong Ren

Kevin Colbert

Kevin Feng

Georgia C Yalanis

Ji Suk Choi

John-Michael Williford

Brian Honewee Cho

Jun Wang

Justin Scot Hanes

Irina Nikolaevna Kadiyala

Peter John McDonnell

Hungnan Lo

Qingguo Xu

Ahmet Hoke

Calvin Chang

Wen Jie

Fabiana Kimie Kashiwabuchi

Martin Gilbert Pomper

Kevin D McIntosh

Sharon Gerecht

Thomas August

Il Minn

Bart S Hendriks

Seeram Ramakrishna

Chee Mun Kuan

Xi Liu

Vu L Truong

Brian Patrick Ginn

Kunal S Parikh

Luc Douay

Weiping Li

Michael F Haller

Krishnendu Roy

Lloyd S Miller

Sebastian F Barreto Ortiz

Alyssa Ashbaugh

Jesse Zheng

Shawn H Lim

Xingyu Liu

Robert Wood

Corinne Keet

Ramasamy Sakthivel

Donald J Brown

Vincent J Pompili

Hiranmoy Das

Yukang Zhao

John Michael Williford

Ibrahim Zuhaib

Kian-Ngiap Chua

Kellin Krick

Maani Archang

Karim A Sarhane

Ren-Xi Zhuo

Kevin Y Lin

Wensin Dang

Shawn Hwei-In Lim

The presently disclosed composition and methods are provided for a nanofiber-hydrogel composite containing adipose cell binding moieties. A method for healing a soft tissue defect can include applying an adipose cell-binding composite material to a soft tissue defect in combination with exogenous adipose-derived cells or endogenous cells recruited from the surrounding tissue.

Mesenchymal cell-binding composite material for tissue restoration

The presently disclosed subject matter provides methods for continuously generating uniform polyelectrolyte complex (PEC) nanoparticles comprising: flowing a first stream comprising one or more water-soluble polycationic polymers at a first variable flow rate into a confined chamber; flowing a second stream comprising one or more water-soluble polyanionic polymers at a second variable flow rate into the confined chamber; and impinging the first stream and the second stream in the confined chamber until the Reynolds number is from about 1,000 to about 20,000, thereby causing the one or more water-soluble polycationic polymers and the one or more water-soluble polyanionic polymers to undergo a polyelectrolyte complexation process that continuously generates PEC nanoparticles. Compositions produced from the presently disclosed methods and a device for producing the compositions are also disclosed.

Methods of preparing polyelectrolyte complex nanoparticles

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

Nanofiber-hydrogel composites for cell and tissue delivery

Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration

The presently disclosed subject matter provides a scalable and electrostretching approach for generating hydrogel microfibers exhibiting uniaxial alignment from aqueous polymer solutions. Such hydrogel microfibers can be generated from a variety of water-soluble natural polymers or synthetic polymers. The hydrogel microfibers can be used for controlled release of bioactive agents. The internal uniaxial alignment exhibited by the presently disclosed hydrogel fibers provides improved mechanical properties to hydrogel microfibers, and contact guidance cues and induces alignment for cells seeded on or within the hydrogel microfibers.

Electro-mechanically stretched micro fibers and methods of use thereof

A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

Composite material for tissue restoration

The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

Fiber-hydrogel composite surgical meshes for tissue repair

Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at least one polyethylene glycol (PEG) polymer having an average molecular weight less than 1 kDa, and at least one nucleic acid, wherein the graft or block copolymer and at least one nucleic acid are complexed and condensed into a shaped micellar nanoparticle that is stable in biological media are disclosed. The presently disclosed subject matter also provides a method for preparing the presently disclosed polymeric micellar nanoparticle compositions, a method for targeting at least one metastatic cancer cell in a subject, and a method for treating a disease or condition using the presently disclosed polymeric micellar nanoparticle compositions.

Compositions of nucleic acid-containing nanoparticles for in vivo delivery

The presently disclosed subject matter provides a coating composition which allows for the co-delivery of two or more bioactive agents with independent control of loading level and release profile for each bioactive agent, an implantable medical device coated with the coating composition, and methods for preparing the coating composition.

Compositions and methods for preparation of composite polymer coatings on medical implants, and their use for co-delivery of multiple antimicrobial agents

The present invention is directed to a device and method for a nanofiber wrap to minimize inflation and scarring of nerve tissue and maximize the nutrient transport. More particularly, the present invention is directed to a novel semi-permeable nanofiber construct prepared from biocompatible materials. The nanofiber construct is applied around a nerve repair site following end-to-end anastomosis. The nanofiber construct is porous and composed of randomly oriented nanofibers prepare using an electrospinning method. The nanofiber construct has a wall that is approximately 50-100 &#x3bc;m thick with pores smaller than 25 &#x3bc;m. The nanofiber construct prevents inflammatory cells from migrating into the nerve coaption site, while still permitting the diffusion of growth factors and essential nutrients. The nanofiber construct allows for enhanced neuroregeneration and optimal function outcomes.

Device and method for a nanofiber wrap to minimize inflamation and scarring

Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. In a preferred embodiment the suture materials are made from a poly(hydroxyl acid) such as poly(1-lactic acid) and a polyalkylene oxide such as poly(ethylene glycol) or a polyalkylene oxide block copolymer. The sutures entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month.

Methods of making drug loaded microfiber sutures for ophthalmic application

Growing community of inventors

Baltimore, MD, United States of America

Hai-Quan Mao