Sk Biopharmaceuticals Co., Ltd.

Hae-Jeong Yoon

Won Sik Kim

Won Hee Kim

Yu-Jin Shin

Chun-Eung Park

Yong-Je Shin

Eun-Ju Ryu

Kyung-Hyun Min

Ki-Ho Lee

Coo-Min Chung

Hui-Ho Kim

Kyung-Hyan Min

There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I): or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing the subject compounds. The subject compounds are useful for the treatment of diseases of the central nervous system, particularly depression, anxiety and pain disorder.

3 or 4-substituted piperidine compounds

Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject compounds are also disclosed. The subject compounds are useful for the treatment of diseases of the central nervous system, such as depression, anxiety and pain disorders.

3-substituted propanamine compounds

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Daejeon, South Korea

Hae-Jeong Yoon