Sk Chemicals Co., Ltd.

Hae In Rhee

Keun Ryu

Yong-Baik Cho

Chang-Kyun Han

Wie-Jong Kwak

Jung Bum Yi

Joo Hyon Kim

Nam Ho Kim

Nam Kyu Lee

Je Ho Ryu

Key An Um

So Yoon Lee

Hunseung Yoo

Do Seung Kum

In Ho Jung

Hun Seung Yoo

Hee Jae Shin

Hyung Ook Kim

Taek Su Kim

Ki Won Joung

Jae Yoon Jung

Keun Ho Ryu

The present invention relates to a herbal drug composition for cartilage protection comprising plant extracts of Clematis Radix, Trichosanthis Radix, and Prunellae Spica and an optimal content of rosmarinic acid to: (i) alleviate pains; (ii) inhibit the acute/chronic inflammation, platelet/whole blood aggregation, immunocyte (B-lymphcyte and T-lymphcyte) proliferation, inflammation-inducing enzyme activities, and enzyme activities associated with degradation of joint tissue; (iii) scavenge activity of toxic active oxygen radicals; and (iv) further provide excellent cartilage protection activity to be effectively used as an anti-inflammatory agent with analgesic effects, blood circulation enhancer, arthritis therapeutic agent and cartilage protective.

Herbal drug composition for cartilage protection

The invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.

Pyridine derivatives, a process for their preparation and a pharmaceutical composition containing the same

Disclosed is a method for extracting and purifying active constituents from honeysuckle (Thunb.) and its use. More particularly, this invention relates to an extraction and purification method of active constituents including sweroside from for honeysuckle stem (stem of honeysuckle where leaves are removed) by removing tannins, hardly soluble flavonoids, saponins, and the like. Thus obtained active constituents have better anti-inflammatory and analgesic effect, are safer and more stable than the conventional active constituents obtained from honeysuckle flower or honeysuckle leaves, and include sweroside which is an effective active ingredient of anti-inflammatory and analgesic drug.

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Seoul, South Korea

Hae In Rhee