Dong-a Socio Holdings Co., Ltd.

Hadong Kim

Seong Jin Park

Jin Kwan Kim

Ki Moon Ryu

Taeyoung Yoon

Mi Yeon Jang

Sumin Kim

Taesun Park

Myeong-Seop Kim

Joon-Ho Sheen

Mi Na Jang

Compounds of formula (I) [Formula should be inserted here] and a pharmaceutically acceptable salt thereof, wherein A, R, R, R, R, R, R, R, R, X, L, n and p are as defined in the specification, are useful for treating or preventing Mer tyrosine kinase receptor modulated disease or conditions. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Heteroaryl compounds and their use as Mer inhibitors

The present invention provides heterocyclic compounds, the stereoisomer thereof, the enantiomer thereof, or the pharmaceutically acceptable salt, which are capable of modulating the activity of Mer receptor tyrosine kinase (MERTK). This invention also provides pharmaceutical compositions thereof, methods to prepare the said compounds, and the use of such compounds as a medicament. The present invention is directed to MERTK inhibitory compounds with marked potency, thereby having an outstanding potential for a pharmaceutical intervention of cancer and any other diseases related to MERTK dysregulation.

Heteroaryl compounds and their use as therapeutic drugs

Compounds of formula (I) and a pharmaceutically acceptable salt thereof, wherein A, R, R, R, R, R, R, R, R, X, L, n and p are as defined in the specification, are useful for treating or preventing Mer tyrosine kinase receptor modulated disease or conditions. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions. 

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Seoul, South Korea

Hadong Kim