Sunnybrook Research Institute

Hadi Tadayyon

Gregory J Czarnota

Ali Sadeghi-Naini

Lakshmanan Sannachi

William Tyler Tran

Mehrdad Gangeh

Omar Falou

Systems and methods for using quantitative ultrasound ('QUS') techniques to generate imaging biomarkers that can be used to assess a prediction of tumor response to different chemotherapy treatment regimens are provided. For instance, the imaging biomarkers can be used to subtype tumors that have resistance to certain chemotherapy regimens prior to drug exposure. These imaging biomarkers can therefore be useful for predicting tumor response and for assessing the prognostic value of particular treatment regimens.

Systems and methods for prediction of tumor response to chemotherapy using pre-treatment quantitative ultrasound parameters

Systems and methods for classifying tissue using quantitative ultrasound techniques. Parameters are calculated directly from raw echo signal data acquired from a region-of-interest during an ultrasound scan and parametric maps are produced using these parameters. These parameters can be calculated after normalizing the echo signal data using reference data so as to mitigate the effects of variations in instruments settings, ultrasound beam diffraction, and attenuation effects. First-order and second-order statistical measures are computed from these parametric maps, and are used to classify the tissue or tissues in the region-of-interest. Using these systems and methods, tissue can be classified with different levels of classification. For example, a tissue characterized as malignant cancer can additionally be graded (e.g., Grade I, II, or III).

System and method for classifying and characterizing tissues using first-order and second-order statistics of quantitative ultrasound parametric maps

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North York, Canada

Hadi Tadayyon