Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Hadassah Sumum Sade

Carola Ries

Sabine Hoves

Fabien Gaire

Dominik Ruettinger

Oliver Grimm

Solange Romagnoli

Suzana Vega Harring

Chia-Huey Ooi

The current invention relates to the intermittent dosing of an anti-CSF-1R antibody in combination with macrophage activating agent, corresponding pharmaceutical compositions or medicaments using such combination therapy.

Method of treating cancer in a patient by administering an antibody which binds colony stimulating factor-1 receptor (CSF-1R)

The system is configured to receive at least one digital image of a tissue sample of a patient; analyze the at least one received image for identifying tumor cells in a region of the at least one received image; analyze the at least one received image for identifying FAP+ areas in the region, each FAP+ area being a pixel blob representing one or more cells express the fibroblast activation protein&#x2014;'FAP'; analyze the at least one received image for identifying distances between the identified tumor cells and their respective nearest FAP+ area; computing a proximity measure as a function of the identified distances; process the proximity measure by a classifier for generating a classification result, the classification result indicating if the tumor of the patient can be treated by a drug or drug-component that binds to FAP; and output the classification result.

Distance-based tumor classification

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Penzberg, Germany

Hadassah Sumum Sade