Korea Research Institute of Bioscience and Biotechnology

Jeju National University Industry-Academic Cooperation Foundation

Jeju National University-Academic Cooperation Foundation

Hack Sun Choi

Chul Ho Kim

Baek Rock Oh

Jung Hyun Ju

Jong Jae Yi

Young Bae Kim

Jeong Woo Seo

Sun Yeon Heo

Dong Kee Jung

Dong Sun Lee

Dong-sun Lee

The present invention relates to a novel enzyme capable of producing multi-hydroxy derivatives from polyunsaturated fatty acids and a method for producing multi-hydroxy derivatives of polyunsaturated fatty acids using the same.

Method for producing multi-hydroxy derivatives of polyunsaturated fatty acids

Disclosed are a composition and a perfume composition for inhibiting growth of breast cancer stem cells containing phenylacetaldehyde or a pharmaceutically acceptable salt thereof as an active (effective) ingredient, and a pharmaceutical composition, a food composition or the like for inhibiting metastasis of breast cancer, or treating or preventing breast cancer, including the composition. The phenylacetaldehyde inhibits growth of breast cancer cells and formation of breast cancer stem cells. In addition, the phenylacetaldehyde inhibits expression of self-renewal genes such as Nanog, Sox2, Oct4, and CD44 known to be specifically expressed in breast cancer stem cells, inhibits production of IL-6 known to be involved in formation of mammospheres of breast cancer stem cells, and inhibits STATS signaling pathways. Accordingly, the compound inhibits growth of breast cancer stem cells and is useful for the treatment of breast cancer.

Composition for inhibiting growth of breast cancer stem cells containing phenylacetaldehyde

The present invention relates to a composition for inhibiting the growth of cancer stem cells, which includes ciclesonide or a pharmaceutically acceptable salt thereof as an active ingredient, a pharmaceutical composition or food composition for inhibiting cancer metastasis, or treating or preventing cancer, which includes the composition, and the like. Ciclesonide of the present invention inhibits the growth of breast cancer cells and lung cancer cells, and inhibits the formation of breast cancer stem cells and lung cancer stem cells. In addition, it was confirmed that ciclesonide inhibited the expression of self-renewing genes such as Nanog, C-myc, Oct4, Sox2, Snail, and CD44, which are known to be characteristically expressed in breast cancer stem cells and lung cancer stem cells, inhibited the production of IL-6 and IL-8, which are known to be involved in the formation of mammospheres of breast cancer stem cells and the formation of tumorspheres of lung cancer stem cells, and inhibited the STAT3 signaling pathway. Accordingly, the compound inhibits the growth of cancer stem cells such as breast cancer stem cells, lung cancer stem cells, and the like and the growth of these cancers, and thus may be used for the treatment of cancer such as breast cancer, lung cancer, and the like.

Composition for inhibiting a growth of cancer stem cells comprising ciclesonide

Growing community of inventors

Jeju-si, South Korea

Hack Sun Choi