Fujisawa Pharmaceutical Company, Ltd.

Hachiro Seno

Masaaki Matsuo

Takashi Ogino

Kyoichi Shimomura

Norihiro Igari

Toshiyasu Honbo

Michihisa Nishiyama

Macrolide compounds such as the FR-900506 and its related compounds are provided for the prevention or treatment of idiopathic thrombocytopenic purpura and Basedow's disease. Composition containing such compounds is also disclosed.

Medicament for treating idiopathic thrombocytopenic purpura

Compounds of the formula: ##STR1## wherein A is S, SO, or SO.sub.2, R.sup.1 is H or acyl, R.sup.2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R.sup.3 is pyridyl are claimed. The compounds are useful as therapeutic agents for the treatment of e.g. rheumatism, nephritis and thrombocytopenia.

Thiazole derivatives, processes for production thereof and

Compounds of the formula: ##STR1## wherein A is S, SO, or SO2, R1 is H or acyl, R2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R3 is pyridyl are claimed. The compounds are useful as therapeutic agents for the treatment of e.g. rheumatism, nephritis and thrombocytopenia.

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Kadoma, Japan

Hachiro Seno