Korea Ocean Research and Development Institute

Korea Institute of Ocean Science & Technology

Sn Bioscience Inc.

Korea Ocean Research Institute

Ha Ju Park

Joung Han Yim

Se Jong Han

Tai Kyoung Kim

Sung Jin Kim

Pil-Sung Kang

Il Chan Kim

Hyoung Seok Lee

Jung Eun Kim

Heeyong Park

Dong-Gyu Jo

Doc Kyu Kim

Mi Ra Park

Il-Chan Kim

Dockyu Kim

Hyun Cheol Oh

Yu-Kyung Park

Pyung Cheon Lee

Cheolsoon Lee

Bhattarai Hari Datta

Keun-Sik Kim

Jun Hyuck Lee

Chul Soo Shin

Sung Gu Lee

Bon-Hun Koo

Min Ju Kim

Hong Kum Lee

Ui Joung Youn

Babita Paudel-Bhattarai

Pil Sung Kang

Ju Mi Hong

Seul Ki Min

Kyung Hee Kim

Dong Gyu Jo

Yu-Kyeong Park

Jin Haeng Song

Hye Yeon Koh

Seung Jin Kim

Suhkneung Pyo

Jong Han Yim

Ii Chan Kim

A lobamide compound according to an embodiment of the present disclosure is represented by Formula 1. The lobamide compound has excellent PTP-1B inhibitory activity that is far higher than that of conventional lobaric acid derivatives and which can be orally administered, and thus is very effective in the prevention or treatment of diabetes or obesity through oral administration.

Lobaric acid derivative having PTP-1B inhibitory activity, preparation method therefor and use thereof

The present invention relates to an exopolysaccharide derived fromsp. strain CY01 (KCTC 12867BP) which is a novel strain living in the polar regions, and to a composition for cryoprotection of cells, which contains the exopolysaccharide. The exopolysaccharide of the present invention has an excellent ability to cryoprotect cells, and shows no cytotoxicity. Thus, the inventive exopolysaccharide can substitute for conventional cryoprotective agents that show cytotoxicity when used at high concentrations.

Cryoprotective agent containing exopolysaccharide fromsp. CY01

A cold-adapted protease derived fromPAMC 21717 or a recombinant cold-adapted protease obtained by expressing a gene encoding the cold-adapted protease inis described, and more particularly, a crystal of a protease exhibiting activity at low temperatures, a method for crystallizing the protease, a method for preparing the protease, a recombinant microorganism that expresses the protease, a method for preparing the recombinant microorganism, a method for preparing the recombinant protease and the use of the cold-adapted protease. The cold-adapted protease exhibits high activity at low temperatures, and securely maintains its enzymatic activity even in the presence of high pH, various metal ions and surfactants. Thus, it is useful in various industrial applications.

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The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-&#x3ba;B, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin

The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes.

Method for preparing ramalin

The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Pharmaceutical and food compositions for preventing or treating diabetes or obesity

Growing community of inventors

Gyeonggi-do, South Korea

Ha Ju Park