The General Hospital Corporation

Ortho Pharmaceutical Corporation

Johnson Matthey Inc.

Massachusetts General Hospital Corporation

H William Strauss

Robert H Rubin

Richard Hardwick Moore

Ban A Khaw

Nathaniel M Alpert

Faina Shtern

Gary James Bridger

Alan J Fischman

John D Higgins, Iii

Daniel J Kroon

Scott K Larsen

Koon Y Pak

Harvey J Berger

Claudia K Derian

Howard F Solomon

Pedro E Hernandez

Anthony J Fuccello

The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure

Labeled chemotactic peptides to image focal sites of infection or

The invention relates to a method of detecting an inflammation site in an individual by administering to the individual a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site when the site is inflamed.

Method for the diagnosis and treatment of inflammation

The invention relates to a method of detecting an Fc receptor-expressing tumor site in an individual by administering to the individual a diagnostically effective amount of detectably-labeled non-specific immunoglobulin or Fc or Fc' fragment thereof, wherein the immunoprotein substantially accumulates at the site when the site bears such a tumor. By using a therapeutically-labeled specific or non-specific immunoglobulin or Fc or Fc' fragment thereof, the tumor may be treated therapeutically.

Method for tumor detection and treatment

Method for tumor detection

Method using technetium-99m imaging agents for the study, detection or diagnosis of ischemic, infarcted or diseased tissue. The imaging agents comprise a complex of technetium-99 m and glucarate.

Organ infarct imaging with technetium labelled glucarate

An ambulatory ventricular function anaylzer system is provided. The ambulatory ventricular function analyzer system is carried by a garment worn by a cardiac patient and includes ECG electrodes, a main left ventricular probe detector, and a background lung probe detector for providing diagnostically useful information while the patient goes about the normal activities of daily life. An information processing sub-system including a microprocessor responds to the electrode signal and to the probe signals and provides composite data representative of the ECG activity, the background lung time-activity, the left ventricular time-activity, and an R-wave histogram averaged over multiple cardiac cycles. The averaged data is sequentially sotred over a long time interval on magnetic tape in plural categories representing premature ventricular contraction, postpremature ventricular contraction, and normal ventricular contraction for subsequent display on a computer-based graphics display for study by a cardiac specialist. The main left ventricular function probe detector includes an array of cadmium telluride crystals mounted in a Pb housing having a parallel hole Pb collimator. The detector is substantially insensitive to position changes that arise during ambulatory monitoring.

Ambulatory ventricular function monitor

A vest for positioning medical instrumentation about the human or animal torso to provide ambulatory monitoring of patient cardiac functions or administration of medication or therapy with reasonable freedom of movement while maintaining precise positioning of the instrumentation relative to the torso. The vest functions to provide accurate placement of such instrumentation as a radioactive emission sensor for monitoring ejection fraction. The vest typically includes a sheet of a dimensionally rigid material such as a low density polymer tailored to fit between neck and hips and to surround the torso, terminating on the back. Straps are provided to fasten the sheet ends together at the back and to suspend it from the shoulders. The vest may also be instrumented to function as a transducer itself to detect chest expansion for heart beat or lung volume monitoring.

Body hugging instrumentation vest having radioactive emission detection

A variable angle radiation collimator particularly for use in gamma-photon medical diagnostic systems in a gamma-photon camera system for radiological examination of human subjects. The collimator provides collimation of gamma-photon radiation along a single beam direction which may be varied along two axes to adjust exposure angle or to provide a scanning capability. The collimator is a stack of substantially identical radiation-opaque plates, each of which are apertured with a similar array of openings. The combined effect of the stacked aperture plates is to transmit radiation in a predetermined orientation. The collimated angle of the radiation thus generated is controlled by the coincidence of the array of openings. The stack is retained by a mechanism which permits adjustment of the collimation angle, and the plates are fabricated to provide ease of shear motion during such adjustment. In addition, the tradeoff between the resolution and intensity of radiation transmitted may be easily varied by adjusting stack thickness.

Variable angle slant hole collimator

Growing community of inventors

Newton, MA, United States of America

H William Strauss