Sloan-kettering Institute for Cancer Research

H Richard Beresford

Lloyd J Old

Kenneth O Lloyd

Alan N Houghton

Wolfgang J Rettig

Pilar Garin-Chesa

Herbert F Oettgen

Anthony P Albino

M Jules Mattes

Myron R Melamed

J Gregory Cairncross

This invention provides a method of identifying mesenchymal tissues as normal, proliferatively active or malignant. This invention also provides a method of distinguishing subsets of sarcomas with distinctive antigenic phenotypes. This invention also provides a method of diagnosing mesenchymal tumors. Finally, this invention provides a monoclonal antibody designated G171 and the hybridoma cell line producing said monoclonal antibody (ATCC No. HB9254).

Cell-surface glycoproteins of human sarcomas

Method of forming an antibody producing hybridoma cell line by fusing a myeloma cell line with splenocytes derived from BALB/c mice immunized with human astrocytoma tumor cells, the hybridoma cell line formed, and the monoclonal antibodies generated by said hybridoma cell line. A method of phenotyping astrocytoma tumor cells comprising determining the reaction of said cells to various monoclonal antibodies to astrocytoma tumor cells is also provided.

Cell surface antigens of human astrocytoma

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Century Island, NY, United States of America

H Richard Beresford