Leland Stanford Junior University

Honda Motor Co., Ltd.

H Craig Heller

Dennis A Grahn

Daniel Z Wetmore

Craig C Garner

Damien Colas

Hsuan Chang

Anthony N Van Den Pol

Robert M Sapolsky

Lisa Share

Provided herein are methods, drug formulations, and dosing regimens for improving cognitive function in a normal or cognitively impaired subject. For instance, methods provided herein comprise administering a GABAreceptor antagonist so that peak concentration of the GABAreceptor antagonist occurs when the subject is asleep.

Cognitive function

Methods and devices for preventing a change in the core body temperature of a mammal under cold conditions are provided. In the subject methods, a requirement for thermal energy input in said mammal is first detected. In response to the detection of this requirement for thermal energy input, a surface of a portion of the mammal is contacted with a warm temperature medium under negative pressure conditions for a period of time sufficient to introduce thermal energy into the core body of the mammal. The subject devices include at least a means for detecting a requirement for thermal energy input and a means for contacting a surface of the mammal with a warm temperature medium under negative pressure conditions. The subject methods and devices find use in a variety of applications, and are particularly suited for use in maintaining the core body temperature of a mammal substantially constant under cold conditions for an extended period of time.

Methods and devices for prevention of hypothermia in a mammal during prolonged exposure to extreme cold

A system for preventing drowsiness in a driver by employing a thermal grill. The system includes a detection module and an intervention module. The detection module monitors a driver's parameters to determine whether the driver is drowsy. If the driver is determined to be drowsy, the intervention module activates a thermal grill with interlaced hot and cold regions. This activation causes the hot regions to approach one temperature and the cold regions to approach another. Additionally, this activation leads to an uncomfortable sensation for the driver, alerts the driver, and prevents the driver from getting drowsy.

System and method for detecting and preventing drowsiness

Methods for improving cognitive function

Methods and devices for manipulating the thermoregulatory status of a mammal are provided. In the subject methods, thermal energy is transferred between the environment and both of the thoracic/abdominal core body and head of the mammal. In general, thermal energy transfer between thoracic/abdominal core body and the environment occurs under negative pressure conditions. The subject methods and devices can be used to increase the thoracic/abdominal core body temperature of a mammal, in which case thermal energy is introduced into the thoracic/abdominal core body of the mammal and removed from the head of the mammal or cold is merely applied thereto. The subject methods and devices can also be used to reduce the thoracic/abdominal core body temperature of a mammal, in which case thermal energy is removed from the thoracic/abdominal core body of the mammal and introduced into the head of the mammal or heat is merely applied thereto.

Methods and devices for manipulating the thermoregulatory status of a mammal

Methods and devices for extracting thermal energy from the core body of a mammal are provided. In practicing the subject methods, a portion of the mammal, e.g. a limb or portion thereof, is placed in a sealed enclosure to produce an enclosed portion of the mammal. A surface of the enclosed portion of the mammal is then contacted with a low temperature medium under negative pressure conditions for a period of time sufficient to provide for the desired core body thermal energy extraction. The subject methods and devices find use in a variety of applications, e.g. providing relief from temperature sensitive disorders, such as multiple sclerosis, and the treatment of hyperthermia, among other treatments. The subject methods and devices are particularly suited for use in enhancing the physical ability of a mammal.

Methods and devices for extracting thermal energy from the body core of a mammal

Methods, computer programming and devices for transferring heat to and/or from a body portion of a mammal are provided. One approach includes directly determining a state of vasoconstriction or vasodilation in a portion of a body, and supplying heat to the portion of the body when vasoconstriction is determined, and removing heat from the portion of the body when vasodilation is determined. The body portion preferably includes specific heat exchange vasculature. In another approach, a transition of the body portion from a state of vasodilation to vasoconstriction is determined and the body portion is then actively kept in a state of vasodilation while removing heat therefrom.

Controlled heat transfer with mammalian bodies

Low-cost, reliable, easy to use device and method identifies potential drowning or near-drowning events (i.e. a submerged inert human) in a timely manner, provides the precise location of the event, and issues an alert that such an event is in progress. Device is optionally networked to remote monitoring station.

Growing community of inventors

Stanford, CA, United States of America

H Craig Heller