Neovacs

Hélène Le Buanec

Daniel Zagury

Bernard Bizzini

Jean-François Zagury

Jean François Zagury

A stable immunogenic product for the induction of antibodies against one or more antigenic proteins in a subject, characterized in that it comprises proteinaceous immunogenic heterocomplexes which are formed by associations between (i) antigenic protein molecules and (ii) proteinaceous carrier molecules and in that less than 40% of the antigenic proteins (i) are linked to the proteinaceous carrier molecules (ii) by a covalent bond.

Method for preparing a stable TNF-&#x3b1; vaccine

The present invention concerns a novel method for preparing a stable immunogenic product comprising antigenic heterocomplexes of TNF&#x3b1; and a carrier protein, the method steps of which are disclosed in the specification.

Method for preparing a stable immunogenic product comprising antigenic heterocomplexes of TNF&#x3b1; and a carrier protein

The invention relates to an immunogenic or vaccine composition inducing an immune response towards the HPV-16 Papillomavirus native E7 protein, without simultaneously inducing an immunosuppression, said composition comprising, as the active ingredient, a non immunosuppressive mutated E7 protein, comprising the amino acid sequence consisting, from the N-terminal end to the C-terminal end, in:

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Paris, France

Hélène Le Buanec