Synbias Pharma Ag

Other

Bernhardt, Günther

Knör, Günther

Bogner, Udo

Schickaneder, Helmut

Schickaneder, Christian

Günther Bernhardt

Helmut Schickaneder

Michael Limmert

Christian Schickaneder

Armin Buschauer

Stefan Huber

Harald Hofmeier

Mathias Lubbe

Udo Bogner

Günther Knör

The present invention relates to bendamustine derivatives and related compounds of formula (VII), (VIII) and (IX), and medical uses thereof in particular in cancer therapy. 

Bendamustine derivatives and related compounds, and medical use thereof in cancer therapy

This disclosure relates to the release of singlet oxygen by thermally activated decomposition of aromatic endoperoxide molecules in material systems [e.g. polymer (nano)particles or polymer films]. Due to the short lifespan and diffusion length of singlet oxygen, the technical problem is that the majority of the decomposition may only take place if the singlet oxygen molecules can reach the target region. For example, either the penetration of the polymer particles into the cancer cells to be killed, or the settlement of bacteria on an implant coated with the polymer film, must be accomplished. It is necessary to allow adaptation of the time progression of the decomposition for the application. The adaptation is performed by chemically and/or physically modifying the functional structures present in the material system, each made of the molecule forming the endoperoxide and at least one adjacent molecule or the cage formed by all adjacent molecules. Potential applications are in pharmacy and medicine, as well as in production technology.

Material system containing endoperoxide with adaption of decomposition, and applications

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Schierling, Germany

Günther Bernhardt