Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Günter Tovar

Herwig Brunner

Thomas Schiestel

Klaus Pfizenmaier

Matthias Grell

Steffen Rupp

Peter Scheurich

Achim Weber

Angela Hammer

Jürgen Schmucker

Nicole Hauser

The present invention relates to nanoparticles with tumor necrosis factor (TNF) or cytokine immobilized thereon, where TNF or the cytokine is preferably immobilized in the form of a trimer in directed fashion and with retention of its biological activity on the carrier, to methods for the directed immobilization of TNF or cytokine on nanoparticles, to the use of the nanoparticles having immobilized TNF or cytokine for the identification and/or isolation of cytokine- or TNF-binding partners and for the identification and/or isolation of inhibitors of the interaction between TNF or cytokine and its binding partners, to the use of such nanoparticles for preparing a pharmaceutical composition, in particular for the therapy of tumors, and to pharmaceutical and diagnostic compositions which comprise such nanoparticles.

Nanoparticles comprising biologically active TNF which is immobilized on the same

The present invention relates to an improved method for mass spectrometric analysis, in particular for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) using nanoparticles, where an analyte is added to a nanoparticle suspension, and the suspension containing the bound analyte is then deposited directly on a MALDI sample carrier and investigated by mass spectrometry, and to nanoparticles suitable for this method.

Mass spectrometric analysis using nanoparticles

Growing community of inventors

Stuttgart, Germany

Günter Tovar