Rheinische Friedrich-wilhelms-universitat Bonn

Caris Science, Inc.

Universitat Konstanz

Caris Life Sciences Switzerland Holdings Gmbh

Rheinische Friedrich-wilhelms-universitaet Bonn

Tolle, Fabian

Mayer, Günter

Friedrich, Felix

Heckel, Alexander

Günter Mayer

David Spetzler

Mark Miglarese

Heather O'Neill

Michael Famulok

Jan Vinkenborg

Valeriy Domenyuk

Tassilo Hornung

Ursula Maria Katia Schöler

Mohammad Seyed Taghdisi Heidarian

Christina Elsbeth Luense

Valentin Wittmann

Magnus S Schmidt

Alexander Heckel

Silvana Hassel

Sven Burgdorf

Fabian Tolle

Felix Friedrich

Seyed Mohammad Taghdisi Heidarian

Katia Maria Ursula SCHÖLER

Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and therapeutic purposes. The target of the oligonucleotides can be a target such as PARP1, HIST1H1B, HIST1H1D, NCL, FBL, SFPQ, RPL12, ACTB, HIST1H4A, SSBP1, NONO, H2AFJ, and DDX21, or a complex, subunit or fragment thereof.

Therapeutic oligonucleotides

Compositions comprising aptamers, and methods of thereof as carrier molecules in cell-mediated immunotherapies, and activation of antigen-specific T-cell responses.

Aptamers for targeted activation of T cell-mediated immunity

The present invention relates to a method of determining a protein in a sample and the use of the method for the identification of aptamer target proteins.

Method of determining a protein in a sample

Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.

Compositions and methods for aptamer screening

The present invention relates to an aptamer comprising a nucleotide sequence SEQ ID NO: 1, a composition comprising an aptamer, and the use of the aptamer in the diagnosis and treatment of cancer, particularly solid tumors.

Aptamers and use of the aptamers in the diagnosis and treatment of cancer

The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.

Cyclohexane compounds and their use as antibiotics

Growing community of inventors

Bonn, Germany

Günter Mayer