Egis Gyogyszergyar Rt.

Egis Gyogyszergyar

Egis Gyogyszergyar Nyrt

György Levay

Gyula Simig

Gabor Gigler

Jozsef Barkoczy

Gabor Blasko

Andras Egyed

Katalin Pallagi

Karoly Tihanyi

Éva Schmidt

Gábor Gigler

András Egyed

János Wellmann

Geza Szabo

Szabolcs Kertesz

Zoltan Ratkai

Hajnalka Kompagne

Bernadett Martonné Marko

Annamaria Simo

László Gábor Harsing

Márta Agoston

István Gacsalyi

József Barkoczy

Judit Raczne Bajnogel

Anikó Miklosne Kovacs

Péter Kotay Nagy

The invention relates to new 2,3-benzodiazepine derivatives of general Formula (I), (wherein Rstands for methyl, formyl, carboxy, cyano, &#x2014;CH&#x2550;NOH, &#x2014;CH&#x2550;NNHCONHor &#x2014;NRR, wherein Rand Rindependently from each other represent hydrogen or lower alkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); Ris nitro or amino; Rstands for hydrogen, lower alkanoyl or CO&#x2014;NRR, wherein Rand Rindependently from each other stand for hydrogen, lower alkoxy, lower alkyl or lower cycloalkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); Ris hydrogen or lower alkyl; the dotted lines have the following meaning: if Rand Rare not present, the bond between positions Cand Cis a single bond and the bond between positions Cand Nis a double bond; if Rand Rare present, the bonds between positions Cand Cand between position Cand Nare single bonds; and if Ris present and Ris missing, the bond between positions Cand Cis a double bond and the bond between positions Cand Nis a single bond) and salts thereof. The invention compounds have neuroprotective effect.

2,3-benzodiazepine derivatives

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Budakeszi, Hungary

György Levay