Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Chinoin Gyogyszer Es Vegyeszeti

Chinoin Pharmaceutical and Chemical Works Ltd.

Gyula Valovics

Jozsef Knoll

Zoltan Meszaros

Agoston David

Sandor Makleit

Rezso Bognar

Zsuzsanna Furst

Istvan Hermecz

Attila Mandi

Gabor Nagy

Peter Szentmiklosi

Sandor J Nagy

Laszlo Szlavik

Laszlo Szavik

A pharmaceutical composition with synergistic analgesic effect which comprises an effective amount of 6-desoxy-6-azido-14-hydroxy-7,8-dihydro morphine or codeine or an analgesically effective salt thereof and an effective amount of a compound ##STR1## wherein R.sup.1 and R.sup.2 are lower alkyl and R.sup.3 is hydrogen or lower alkyl, and the dotted lines represent hydrogenated or unsaturated bonds or an analgesically effective salt or quaternary compound thereof.

Pharmaceutical composition having synergistic analgesic activity and

Pharmaceutical compositions of synergistic analgesic activity are provided which comprise an azido compound of the following formula: ##STR1## or a salt thereof wherein R is hydrogen, methyl, ethyl, acetyl or morpholino-methyl and a compound of the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 are hydrogen or lower alkyl and the dotted lines represent hydrogenated bonds or olefinic bonds and pharmaceutically acceptable salts and quaternary salts thereof, in admixture with suitable inert solid or liquid carriers or dilutents.

Pharmaceutical composition having synergistic analgesic activity

A pharmaceutical composition having synergistic analgesic effect which includes an azido compound of the formula: ##SPC1## namely an azido morphine or an azido codeine, and at least one compound of the formula: ##SPC2## The synergistic composition has been found to have less narcotic side effects than morphine and equal or better analgesic properties.

An analgesic substitute for morphine comprising the synergistic combination of azidomorphine or azidocodeine with a pyrimidazolium.

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Tiszavasvari, Hungary

Gyula Valovics