Richter Gedeon Vegyeszeti Gyar Rt

Magyar Aluminiumipari Troszt

Institute for Drug Research Ltd.

Gyogyszerkutato Intezet

Egis Gyogyszergyar

Egis Gyogyszergyar Rt.

Alkaloida Vegyeszeti Gyar

Gyogyszerkutato Intezet Kft.

Labor Muszeripari Muvek

Femipari Kutato Intezet

Aluterv Aluminiumipari Tervezo Vallalat

Almasfuzitoi Timfoldgyar

Aquatech Kernyezeteedelmi

Richer Gedeon Vegyeszet

Gyula Horvath

Gabor Ambrus

Imre Moravcsik

Istvan Barta

Eva Ilkoy

Karoly Solymar

Antonia Jekkel

Gyorgy Somogyi

Istvan M Szabo

Attila Andor

Karoly Albrecht

Julianna Mozes Nee Suto

Ildiko Lang

Margit Bidlo Nee Igloy

Sandor Boros

Janso Salat

Attila Konya

Sandor Bajusz

Tamas Hamori

Gyorgy Cseh

Jeno Korosi

Peter Botka

Eva Barabas

Daniel Bagdy

Jozsef Zoldi

Istvan Pallagi

Jozsef Boros

Istvan Voros

Bela Toth

Maria Orban Nee Kelemen

Laszlo Birincsik

Laszlo Szporny

Gyorgy Hajos

Antal Simay

Ferenc Andrasi

Istvan Elekes

Tibor Balogh

Laszlo Jaszlits

Janos Borvendeg

Jozsef Borsi

Erno Tyihak

Gyorgy Rabloczky

Ilona Bodi

Gabor Zolyomi

Inge Schafer

Geza Szilagyi

Zsolt Csillag

Attila Juhasz

Jozsef Matyasi

Tibor Kalman

Janos Nagy

Andras Varro

Andrea Maderspach

Geza Szentgyorgyi

Emil Mincsovics

Ilona Hermann Nee Szente

Erno Orban

Janos Kiss

Huba Kalasz

Janos Zambo

Laszlo Lengyel

Laszlo Kozma

Ferenc Szederkenyi

Tibor Ferenczi

Peter Siklosi

Laszlo Zsemberi

Ferenc Sitkei

Nandor Makk

Ferenc Vallo

Eva Bozo

Tibor Legat

Pal Bite

Tihamer Pinter

Kalman Wentzely

Gyorgy Kaptay

Endre Szirmai

Kalman Konczol

Andras Javor

Eva Toth-Sarudy

Zoltan Osvald

Ferenc Lazar

Gyorgy Sigmond

Gyongyi Nagy Nee Csokas

Janos Borsos

Andras Feher

Eva Tomori Nee Joszt

Gabriella Szabo

Jozsef Nagy

Katalin Goldschmidt Nee Horvath

Marta Rusz Nee Patfalusi

Csilla Kiss

Maria Bidlo Nee Igloi

Laszlo Birinesik

Nee Dievald Uskert

Roozsa Gyenge

Gaborne Szeker

Laszlone Mohai

Janosne Lavich

Belane Veghelyi

Gyorgyne Szell

Microbial process for preparing pravastatin

Anticoagulant peptide derivatives and pharmaceutical compositions

The invention relates to a process for the preparation of 1-(3-chlorophenyl)-4-methyl-7,8-dimethoxy-5 H-2,3-benzodiazepine of formula (I) ##STR1## in high purity and in a quality suitable for pharmaceutical purposes. According to the invention the reaction of 1 mole of 2-acetonyl-3'-chloro-4,5-dimethoxybenzophenone of formula (II) ##STR2## with 3-7 moles of hydrazine hydrate in an organic solvent or in a mixture of organic solvents at a temperature between 15.degree. C. and 85.degree. C. is carried out in the absence of air oxygen, optionally in the presence of water. The crude product is then recrystallized from an aliphatic alcohol containing 1 to 5 carbon atom(s).

Process for the preparation of high-purity

The invention relates to a novel process for the preparation of 17 .alpha.-hydroxy-20-oxopregnane derivatives of the general formula (I), ##STR1## wherein R.sub.1 means a hydroxy or an oxo group; and

Process for the preparation of steroids bearing

The invention relates to the new 1-(3-chlorophenyl)-4-hydroxymethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof, furthermore to a process for preparing these compounds. The compounds according to the invention possess valuable anxiolytic, antiaggressive and antidepressant effects and have at the same time favorable acute toxicity values, so they can be used to advantage in therapy.

5H-benzodiazepin derivative

9.alpha.-hydroxy-3-oxo-4,24(25)-stigmastadien-26-oic acid derivatives, a

The method of the invention is advantageously applicable to realize a multistage chemical process during which liquid clarifiers suitable for the purification of water and sewage, furthermore, fine-disperse pulverulent solid products utilizable as pait pigments and fillers may be recovered. Each final product of the multistage chemical processes is a useful material, so the whole technology is waste free.

Method for the multistage, waste-free processing of red mud to recover

The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof. The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.

Novel dihydropyridines having calcium antagonistic and antihypertensive

According to the process the grains are led to the surface or ducts of a rotary element farther in than the flange of the rotary element, thus the coarse grains are led to the flange of the rotary element in a counterflow to the sizing medium. In a housing on an impeller deflecting elements are arranged, the carrier medium and the mixture of material to be sized are fed into the housing by medium inlet tubes, and led out by coarse and fine fraction outlet tubes or nozzles, and one inlet disc is arranged above the impeller so that they form an annular assorting space which is divided by deflecting elements into segments, and a passage connected to the inlet tube of the sizing medium is formed between the mantle of the inlet disc and the inner wall of the housing at its upper end, where ducts leading into the assorting space are arranged in the inlet disc farther in than its flange, and which are connected to the carrier medium inlet tube.

Method and apparatus for sizing grains smaller than 300.mu.

The invention relates to new peptide-aldehydes and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. According to a feature of the present invention there are provided new peptide-aldehyde derivatives corresponding to the general formula (I) ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1-6 alkyl group,

Peptide-aldehydes, process for the preparation thereof and

The invention relates to a process for the reduction of sodium hydroxide losses of the Bayer-cycle by modified causticization of red mud which comprises

Process for the reduction of the sodium hydroxide losses of the

The invention relates to new 16-amino-prostaglandin derivatives of general formula I, ##STR1## wherein C-15 and C-16 may have either S or R configuration, Z stands for a hydrogen atom or a lower alkyl group, and their acid addition salts. These compounds can be prepared by removing the ester group and the p-nitrocarbobenzyloxy protective group of a 9.alpha., 11.alpha., 15-trihydroxy-16-p-nitrobenzyloxycarbonylamido-5-cis,13-trans-prostadienoi c acid derivative of general formula XII--wherein C-15 and C-16 may have either S or R configuration and Z stands for a lower alkyl group--in an optional sequence with the limitation that in those compounds of general formula I where Z stands for a lower alkyl group solely the p-nitrocarbobenzyloxy group is removed, and the resulting product of general formula I is optionally converted with an organic or inorganic acid into a salt. The new prostaglandin derivatives of the invention have valuable therapeutical properties, and can be applied as abortive or oxytocic agents.

16-Amino-postaglandin derivatives, their acid addition salts, and a

A linear overpressured thin layer chromatographic apparatus comprises a base plate 3 supporting a sorbent layer 1 over which a membrane 4 is filled. The membrane 4 is externally pressurized by a fluid medium 10. A transparent cover plate 5 is fitted over the membrane 4, and there are sealed inlets 6, 7 passing through the cover plate 5 for the introduction of the mobile phase and the samples.

Linear overpressured thin-layer chromatographic apparatus

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Budapest, Hungary

Gyula Horvath