Richter Gedeon Vegyeszeti Gyar Rt

Egis Gyogyszergyar

Byogal Gyogyszergyar

Gyula Hornyak

Karoly Lempert

Jozsef Fetter

Gabor Doleschall

Karoly Zauer

Gyula Simig

Jozsef Nyitrai

Kalman Harsanyi

Gizella Barta Nee Szalai

Zsuzsanna Visky Nee Gombos

Lujza E Petocz

Ferenc Lorant Bartha

Antal Feller

Marton Fekete

Gabor Gigler

Katalin Grasser

Katalin Szemeredi

Laszlo Kapolnai

Zsuzsanna Orr

Edit Nee Berenyi

Zsuzsanna Gombos Nee Visky

Gizella Szalai Nee Barta

Klara Gaso

Jozsef Nitrai

Gyula Siming

Peter Huszthy

Eniko Szirt

Etelka Pjeczka

The invention relates to new 2-(substituted imino)-thiazolidines, a process for the preparation thereof, pharmaceutical compositions comprising the same, the use of the said 2-(substituted imino)thiazolidines for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new 2-(substituted imino)-thiazolidine derivatives provided by the present invention correspond to the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each represent halogen, nitro, C.sub.1-4 alkoxy or C.sub.1-4 alkyl, which latter may optionally carry one or more halogen substituent(s),

2-(substituted imino)-thiazolidines and process for the preparation

The invention relates to novel iminothiazolidine derivatives of the formula (I), ##STR1## wherein R.sup.1 and R.sup.3 represent, independently from each other, hydrogen or lower alkyl group,

Iminothiazolidine derivatives

The invention relates to compounds of the general formula (X) ##STR1## wherein R is as a removable protecting substituent of the amido group a phenyl group or a benzyl group substituted by one or more alkoxy group(s) having 1-4 carbon atoms and

Azetidinone acetic acid derivatives and process for the preparation

The invention relates to a process for the preparation of the compound of the formula I, ##STR1## which comprises (a.sub.1) splitting off the ethylene ketal protecting group from the azetidinone derivative of the formula IVa, ##STR2## reducing the compound of the formula III thus obtained, ##STR3## treating the resulting compound of the formula II ##STR4## with concentrated aqueous hydrogen chloride solution; or (a.sub.2) reducing the compound of the formula III, treating the compound of the formula II thus obtained with concentrated aqueous hydrogen chloride solution; or (a.sub.3) treating the compound of the formula II with concentrated aqueous hydrogen chloride solution; and isolating the compound of the formula I thus obtained from the reaction mixture. The compound of the formula I is useful as an intermediate in the production of thienamycin, a highly potent antibiotic.

Process for the preparation of aminolactone carboxylic acid

The invention relates to new heterocyclic compounds containing a protected C-acetyl group. More particularly, the invention concerns new compounds of the Formula (V) ##STR1## wherein R is a group suitable for the protection of amides;

Azetidinone-4-carboxylate containing a protected 3-acetyl group and

The invention relates to new heterocyclic compound containing an alkoxycarbonyl and a substituted methyl group a process for the preparation of these and analogeous compound and pharmaceutical compositions containing them. More particularly, the invention concerns compounds of the general formula (IVa) ##STR1## wherein R' is hydrogen, 2-ethoxycarbonylethyl, aryl or a group suitable for a temporary protection of amides and

Heterocyclic compounds containing an alkoxycarbonyl and a substituted

The invention relates to new heterocyclic compounds containing a protected C-acetyl group. More particulary, the invention concerns new compounds of the formula (VI) ##STR1## wherein R.sup.1 is hydrogen or a group suitable for a temporary protection or amides,

Beta-lactam compounds containing a protected C-acetyl group, process for

The invention relates to new heterocyclic compounds containing a C-acetyl group and a process for their preparation. More particularly, the invention concerns new compounds of the formula (III). ##STR1## in which R is a protecting group suitable for temporary protection of amines and amides or an aryl group, and Z is alkyl. The compounds are intermediates in the preparation of penicillins.

Beta-lactam compounds containing a C-acetal group and process for their

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Budapest, Hungary

Gyula Hornyak