Egis Gyogyszergyar Rt.

Egis Gyogyszergyar Nyrt

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Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

György Lévay

József Barkóczy

Gyula Simig

István Gacsályi

Gábor Szénási

László Gábor Hársing

András Egyed

Katalin Pallagi

Péter Kótay Nagy

Éva Schmidt

Gábor Gigler

Csilla Leveleki

Tibor Mezei

Balázs Volk

Krisztina Móricz

János Wellmann

Rita Kapillerné Dezsöfi

Nóra Sziray

László Hársing

István Ling

Bernadett Martonné Markó

Michael Spedding

Zoltán Greff

Ferenc Antoni

Anikó Miklósné Kovács

Hajnalka Kompagne

Miklós Végh

Judit Ráczné Bajnógel

Ferenc Bertha

Zoltán Rátkai

Endréné Flórian

Gábor Szenasi

István Gascályi

Géza Szabó

Péter Kiricsi

Bernadett Markó

Balázs Molnar

József Fetter

József Schindler

István Gacsalyi

Ildikó Nagyné Gyönös

Elemér Fogassy

Katalin Nagy

Compounds of formula (I): wherein: Medicinal products containing the same which are useful in the treatment or prevention of psychiatric and neurological disorders characterized by cognitive deficits.

Dihydro-oxazolobenzodiazepinone compounds, a process for there preparation and pharmaceutical compositions containing them

The present invention is concerned with new indol-2-one derivatives of Formula (I), which have favorable activity profile for the prophylaxis and treatment of disorders in the central nervous or in the cadiovascular system. 

Piperazine derivatives of alkyl oxindoles

The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein Rstands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; Rrepresents hydrogen or halogen; Rdenotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); Rstands for alkyl having 1-7 carbon atom(s); Rrepresents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R, Rand Reach stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or Rand Rtogether represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system. 

Piperazine derivatives of dialkyl oxindoles

The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a Calkyl group or a group of the formula &#x2014;NRR, wherein Rand Rrepresent, independently, a hydrogen atom, a Calkyl group, a Calkoxy group or a Ccycloalkyl group. 

2, 3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient

The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C-alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds. The compounds of the general Formula I exhibit anxiolytic effect and are useful in the treatment of anxiety 

Piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds

The invention refers to novel 2H-pyridazine-3-one derivatives of the formula I, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient. The novel compounds possess neuroleptic effect and can be used, primarily, for the treatment of schizophrenia. In formula I, R stands for a hydrogen atom or a C, alkyl group, X and Y represent, independently, a hydrogen atom, a halogen atom or a group of the formula II, with the proviso that one of X and Y means always a group of the formula II, and then the other one stands for a hydrogen atom or a halogen atom, wherein in formula II n has a value of 1 or 2. 

2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient

The invention relates to substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein Ris hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), Ris hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Rstands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(Calkyl); Z stands for oxygen; or Rand Z together with the groups placed between them form a piperazine ring; and Rstands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.

Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

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Budakeszi, Hungary

György Lévay