Institute for Drug Research Ltd.

Egis Gyogyszergyar Rt.

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Gyorgy Somogyi

Gyula Horvath

Gabor Ambrus

Istvan M Szabo

Attila Andor

Istvan Barta

Karoly Albrecht

Eva Ilkoy

Julianna Mozes Nee Suto

Antonia Jekkel

Ildiko Lang

Margit Bidlo Nee Igloy

Sandor Boros

Janso Salat

Attila Konya

Imre Moravcsik

Tamas Hamori

Laszlo Birincsik

Gabor Kovacs

Lajos Szabo

Antal Simay

Istvan Gyertyan

Gabor Gigler

Ferenc Andrasi

Pal Berzsenyi

Tibor Balogh

Jozsef Reiter

Jeno Korosi

Istvan Tibor Toth

Peter Botka

Gabor Zolyomi

Jeno Marton

Pal Vago

Jozsef Gaal

Erno Orban

Eszter Szentkuti

Anna Bakonyi

Laszlo Harsing

Katalin Horvath

Gyorgyne Mate

Edit Horvath

Laszlo Birinesik

Csilla Kiss

Maria Bidlo Nee Igloi

Nee Dievald Uskert

Roozsa Gyenge

Csaba Szantai

Szilveszter Vizi

Erszebet Birkas

Peter Botka, Deceased

Jeno Korosi, Deceased

Janos Salat

Microbial process for preparing pravastatin

The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new 1-[2-(substituted vinyl)]-3,4-dihidro-5H-2,3-benzodiazepine derivatives according to the invention correspond to the general formula (I), ##STR1## wherein the variables are hereinbelow defined: The new compounds according to the invention affect the central nervous system and can be used to advantage in the therapy.

1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine

The invention relates to a process for the preparation of 1-(3-chlorophenyl)-4-methyl-7,8-dimethoxy-5 H-2,3-benzodiazepine of formula (I) ##STR1## in high purity and in a quality suitable for pharmaceutical purposes. According to the invention the reaction of 1 mole of 2-acetonyl-3'-chloro-4,5-dimethoxybenzophenone of formula (II) ##STR2## with 3-7 moles of hydrazine hydrate in an organic solvent or in a mixture of organic solvents at a temperature between 15.degree. C. and 85.degree. C. is carried out in the absence of air oxygen, optionally in the presence of water. The crude product is then recrystallized from an aliphatic alcohol containing 1 to 5 carbon atom(s).

Process for the preparation of high-purity

The invention relates to novel racemic or optically active berban derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group 1 to 6 carbon atoms or R.sup.1 and R.sup.2 together represent a C.sub.1-3 alkylenedioxy group;

Berban derivatives as .alpha..sub.2 -adrenergic antagonists

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Budapest, Hungary

Gyorgy Somogyi