Takeda San Diego, Inc.

University of California

Gyorgy Snell

Clifford D Mol

Douglas R Dougan

Raymond C Stevens

Earl Cornell

Robert A Nordmeyer

Derek T Yegian

Bernard D Santarsiero

Alexei Brooun

Ellen Chien

Hua Zou

Michelle L Kraus

William F Kolbe

Thomas N Earnest

Carl W Cork

Mark Knuth

Joseph M Jaklevic

Ciaran N Cronin

Bi Ching Sang

Oleg Brodsky

Kheng Lim

Joseph M Jaklevich

Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and methods of using crystals comprising PDE4-D3.

Crystallization of the catalytic domain of human phosphodiesterase 4-D3 (PDE4-D3)

Provided are crystals relating to the carboxyltransferase domain of human Acetyl-Coenzyme A Carboxylase 2 and its various uses.

Crystallization of carboxyltransferase domain of Acetyl-CoEnzyme A Carboxylase 2 with a ligand

Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses.

Crystallization of MAPK/ERK Kinase 2

A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

Integrated crystal mounting and alignment system for high-throughput biological crystallography

Provided are crystals relating to human Glucocorticoid Receptor and its various uses.

Crystallization of Glucocorticoid Receptor

Growing community of inventors

Richmond, CA, United States of America

Gyorgy Snell