Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Biorex Kutato Es Fejleszo Rt.

Gyorgy Dorman

Gabor Kovacs

Istvan Stadler

Geza Galambos

Sandor Virag

Istvan Tomoskozi

Jozsef Ivanics

Peter Gyory

Pal Hadhazy

Karoly Kanay

Gyula Papp

Peter S Kormoczy

Laszlo Szekeres

Jeno Marton

Karoly Kanai

Andrea Jednakovits

Mihaly Barabas

Peter Kormoczi

Eva Udvary

Miklos Kiss

Istvan Tomoskozy

Marianna Kovacs

Peter Kormoczky

Sandor Erdo

Erno Bacsy

Marta Vitai

Gyorgy Schmidt

Marta Sinka

Magdolna Torok

Pharmaceutical products for curing and preventing illnesses connected

The invention relates to novel interfuranylene-prostacyclin derivatives of the general formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or a straight or branched chain C.sub.1-6 alkyl group, an inorganic cation or for the protonated form of a base containing an amino group;

Interfuranylene prostacyclins

The invention relates to new 7-oxo-PGI.sub.2 -ephedrine salt analogues of the Formula I ##STR1## wherein A stands for --(CH.sub.2).sub.2 --, cis or trans --CH.dbd.CH-- or --C.tbd.C--;

7-oxo-PGI.sub.2 -ephedrine salts and their pharmaceutical compositions

Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation, R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or --C.dbd.C--, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

Selective biologically active 7-oxo-prostacyclin derivatives and

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Budapest, Hungary

Gyorgy Dorman