Richter Gedeon Vegyeszeti Gyar Rt

Gyorgy Dobo

Lajos Kovacs

Csaba Szantay

Lajos Szabo

Lajos Kisfaludy

Gyorgy Fekete

Lajos Dancsi

Karola Jovanovics

Csaba Lorincz

Erno Tyihak

Eszter Dezseri

Miklos Low

Karoly Lapis

Bela Szende

Lajos Balaspiri

Laszlo Varga

Vince Varro

Botond Penke

Laszlo Kopper

Geza Ivanyi

Bela Szarvady

Janos Lonovics

Judit Low, Nee Kaloczy

Andreas Jeney

Karoly Simon

Kalman Kovacs

Peter Pallai

There are disclosed pharmaceutical compositions comprising at least one cytostatic agent and N.sup..epsilon. -trimethylthyllysin or a pharmaceutically acceptable salt thereof, optionally in association with conventional pharmaceutical carriers and other additives. The new compositions possess a reduced toxicity compared with the cytostatic agents administered alone.

Pharmaceutical compositions and process for the preparation of same

Tumor inhibiting alkaloids are recovered from Vinca Rosea L. by a method which comprises extracting the dried leaves with a solvent selected from the group consisting of an alkanol having 1 to 5 carbon atoms, a mixture of an alkanol having 1 to 5 carbon atoms and a dilute, aqueous solution, benzene and benzene homologs; subsequently purifying the alkaloid extract obtained by a phase-change method between immiscible solvents, precipitating the main amount of dimeric alkaloids in form of their sulphuric acid addition salts, isolating leurosine, vincistine, vinblastine, desacetoxy-vinblastine, N-desmethyl-vinblastine and desacetyl-vinblastine from the salt mixture obtained, and then completing the separation and isolation of the remaining alkaloids by separation and isolation by adjusting the pH-value of the mother liquor, after precipitation and removal of the salt mixture, to 5.5 to 10, extracting the solution with a water-immiscible organic solvent and separating vindoline, catharantine, 3',4' -anhydrovinblastine and leurosine from the extract by chromatography, extracting vindoline in the pH-range of 2.5 to 3.5 and catharantine 3',4'-anhydrovinblastine and leurosine in the pH-range of 5 to 6 with benzene or a benzene homologue, from the mother liquor obtained when isolating the salt mixture, and separating a mixture of leurosine and 3',4'-anhydrovinblastine by crystallization, epoxidizing this mixture with an oxygen source, or separating the mixture into its components by chromatography, and subsequently epoxidizing the 3',4'-anhydrovinblastine component to leurosine, and isolating catharantine remaining from the mother liquor obtained when separating the crystalline mixture, or separating the extract containing catharantine, 3',4'-anhydrovinblastine and leurosine into its components by chromatography.

Process for the isolation of alkaloid components from the plant Vinca

A process for the preparation of L-aspartyl-(O-sulfato-L-tyrosyl)-L-methionyl-glycyl-L-tryptophyl-L-methion yl-L-aspartyl-L-phenylalanine amide, which comprises treating the protected octapeptide amide of the general formula (II) ##STR1## wherein X is BOC, Cbz or Ddz,

Process for the preparation of the cholecystokinin-pancreozymin

Growing community of inventors

Budapest, Hungary

Gyorgy Dobo