The University of Akron

Biogal Gyogyszerarugyar Rt

Gyorgy Deak

Joseph P Kennedy

Vilmos Keri

Janos Balint

Miklos I Zsuga

Istvan Melczer

Janos Kelemen

Edit Nagy

Anita Karczub

Gyongyi Strbka

Berta Mako

Ferenc Radnai

Erno Karacxony

Gyula Marton

Laszlo Hanak

Sandor Keki

Csaba Hajdufi

Tibor Szanya

Judit Dencs

A dynamic star polymer contains a plurality of at least three substantially identical block copolymers, each block copolymer including an aromatic polymer moiety having a glass transition temperature of at least about 95.degree. C., and an aliphatic polymer moiety incompatible with the aromatic polymer moiety. The aromatic moieties of each of the formed block copolymers aggregate to form a chemically uncrosslinked core, while the aliphatic polymer moieties radiate outwardly from the core. The multi-arm star polymer is uniquely capable of changing its molecular structure under external influences, and the core thereof preferably exhibits thermoplastic characteristics.

Dynamic star polymers and a method for the synthesis thereof

A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80.degree. C. to about 115.degree. C., melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol.

Process for the purification of cyclosporin A

Growing community of inventors

Debrecen, Hungary

Gyorgy Deak