Richter Gedeon Vegyeszeti Gyar Rt

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Alkaloida Vegyeszeti Gyar

Patentbureau Danubia

Gyogyszerkutato Intezet

Gyorgy Cseh

Endre Kasztreiner

Laszlo Jaszlits

Istvan Elekes

Laszlo Tardos

Sandor Elek

Istvan Polgari

Peter Matyus

Geza Szilagyi

Judit Kosary

Edit Kosa

Zsuzsa Huszti

Agnes Kenessey

Gyula Horvath

Gabor Ambrus

Gyorgy Rabloczky

Andras Varro

Maria Kuhar Nee Kurthy

Nandor Makk

Eva Toth-Sarudy

Eszter Diesler

Gyongyi Nagy Nee Csokas

Pal Tolnay

Imre Moravcsik

Jozsef Szejtli

Lajos Toldy

Istvan Stadler

Istvan Barta

Janos Borvendeg

Jozsef Borsi

Ilona Bodi

Erzsebet Mago Nee Karacsony

Laszlo Sebestyen

Jozsef Borsy

Eva Bozo

Tivadar Rettegi

Andras Ronai

Klara Czako

Judit Sarossy Nee Kincsesy

Aniko Tegdes

ZSuzanne Lang Nee Rihmer

Gyorgy Rablocsky

Ildiko Pribusz Nee Rapp

Laszlo Czollner

Sarolta Vegvari Nee Gyurki

Laszlo Szam

Laszlo Kaufer

Judit Kincsessy

Magdolna Szejtli Nee Rengei

Aliz Druga

Ilona Berzetei

Gabriella Mezei

Judit Stverteczky Nee Sztrokay

Veronika Szilagyi Nee Pap

Andras Divald

Szilagyi Geza

Ilona Kovacs, Nee Szabo

The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof. The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.

Novel dihydropyridines having calcium antagonistic and antihypertensive

The invention relates to novel 3(2H)-pyridazinone-derivatives of the general formula (I), pharmaceutical compositions containing them and process for their preparation. In the general formula (I) ##STR1## stands for an ethyl or propyl group substituted by a terminal halogen atom or a hydroxyl or NR.sup.1 R.sup.2 group, wherein

3(2H)-pyridazinones and pharmaceutical compositions thereof

The invention relates to novel pyrimido [5,4-b][1,4]oxazine derivatives of the formula (I), and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## wherein R.sup.1 stands for a C.sub.1-4 alkyl group;

Pyrimido[5,4-B][1,4]oxazine derivatives and pharmaceutical compositions

The invention relates to novel pyrazole derivatives with an ergoline skeleton of the general formula I, ##STR1## wherein x . . . y stands for a ##STR2## R is a hydrogen atom or methyl group, R.sub.1 stands for a hydrogen atom, C.sub.1-4 alkyl, carbethoxy or pyridyl-group,

Pyrazole derivatives with an ergoline skeleton, their acid addition

A new method is disclosed for the treatment and prevention of gastrointestinal ulcers or erosions which comprises the administration of a pharmaceutically effective amount of a PGI.sub.2 methyl ester-beta cyclodextrin complex to a patient in need of said treatment wherein the amount of the PGI.sub.2 methyl ester constitutes 1 to 15% by weight of the complex.

Method of treating ulcers and erosions in the gastrointestinal system

The invention relates to new 16-amino-18,19,20-trinor-prostaglandin derivatives of general formula I, having at C-17 a substituted or unsubstituted phenyl group, wherein C-15 and C-16 may have either S or R configuration, Y stands for a hydrogen atom or a lower alkyl group, W stands for a hydrogen atom, halogen atom, hydroxy group, lower alkyl or alkoxy group, and their acid addition salts. These compounds can be prepared by removing the ester group and the p-nitrobenzyloxycarbonyl protective group of a 9.alpha.,11.alpha.,15-trihydroxy-16-p-nitrobenzyloxycarbonylamido-17-pheny l-5-cis,13-trans-18,19,20-trinor-prostadienoic acid derivative of general formula XII--wherein C-15 and C-16 may have either S or R configuration, W is as defined above, and Y stands for a lower alkyl group--in an optional sequence with the limitation that in those compounds of general formula I where W is as defined above and Y stands for a lower alkyl group, solely the p-nitrobenzyloxycarbonyl group is removed, and the resulting product of general formula I is optionally converted with an organic or inorganic acid into a salt. The new prostaglandin derivatives of the invention have valuable therapeutical properties, and can be applied in cattle raising for estrus and birth synchronization, furthermore in the veterinary praxis for the treatment of sterility, chronic endometritis and pyometry.

16-Amino-18,19,20-trinor-prostaglandin derivatives, and acid addition

The invention relates to new 16-amino-prostaglandin derivatives of general formula I, ##STR1## wherein C-15 and C-16 may have either S or R configuration, Z stands for a hydrogen atom or a lower alkyl group, and their acid addition salts. These compounds can be prepared by removing the ester group and the p-nitrocarbobenzyloxy protective group of a 9.alpha., 11.alpha., 15-trihydroxy-16-p-nitrobenzyloxycarbonylamido-5-cis,13-trans-prostadienoi c acid derivative of general formula XII--wherein C-15 and C-16 may have either S or R configuration and Z stands for a lower alkyl group--in an optional sequence with the limitation that in those compounds of general formula I where Z stands for a lower alkyl group solely the p-nitrocarbobenzyloxy group is removed, and the resulting product of general formula I is optionally converted with an organic or inorganic acid into a salt. The new prostaglandin derivatives of the invention have valuable therapeutical properties, and can be applied as abortive or oxytocic agents.

16-Amino-postaglandin derivatives, their acid addition salts, and a

Pyridazinylhydrazones capable of lowering blood pressure have the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;

Novel pyridazinylhydrazones and method of administering same

Pyridazinylhydrazones capable of lowering blood pressure having the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;

Morpholino pyridazinylhydrazones

3-(1-Pyrazolyl)-pyridazine derivatives of the formula I, or pharmaceutically acceptable acid addition salts thereof, which decrease high blood pressure and inhibit catabolism or prostaglandins, ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-4 alkyl,

3-(1-Pyrazolyl)-pyridazine derivatives

The invention relates to novel sulfonamidobenzoic acid derivatives having the general formula ##STR1## wherein R.sup.1 denotes a C.sub.1-4 alkoxy group or a hydrazino group or an NR.sup.4 R.sup.5 group, wherein R.sup.4 and R.sup.5 denote each a hydrogen atom or an identical or different C.sub.1-4 alkyl group; furthermore R.sup.4 may denote an aralkyl or substituted aralkyl group provided that R.sup.5 denotes a hydrogen atom; furthermore NR.sup.4 R.sup.5 may denote a morpholine or piperazine ring;

Sulfonamido-benzoic acid derivatives

The invention relates to compounds of general formula ##STR1## wherein R.sup.1 stands for a hydrogen atom or a C.sub.1-6 alkyl-, a C.sub.2-4 hydroxyalkyl, a C.sub.3-6 cycloalkyl or a phenyl group,

3-(1-Pyrazolyl)-pyridazine derivatives and hypotensive compositions

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Budapest, Hungary

Gyorgy Cseh