Egis Gyogyszergyar Rt.

Gyongyi Vereczkey Nee Donath

Gyula Simig

Tibor Mezei

Zoltan Budai

Attila Mandi

Gabor Blasko

Kalman Nagy

Imre Klebovich

Klara Reiter Nee Esses

Margit Csorgo

Eva Furdyga

Ilona Sztruhar

Laszlo Koncz

Judit Szego

Process for the preparation of 8 -[4 -[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-d ione (buspiron) of the Formula I ##STR1## and the hydrochlorides thereof having high purity by continuously adding a solution of 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-but-2 -inyl]-8-aza-spiro[4.5]decane-7,9-dione of the formula II ##STR2## formed with an inert organic solvent having a concentration of at least 40% by weight to a suspension of a hydrogenation catalyst in an inert organic solvent and optionally converting the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7 ,9-dione thus obtained into the hydrochloride thereof.

Process for the preparation of high purity buspiron and the

Growing community of inventors

Budapest, Hungary

Gyongyi Vereczkey Nee Donath