Food Industry Research and Development Institute

Other

Gwo-Fang Yuan

Yen-Lin Chen

Ing-Er Hwang

Hing-Yuen Chan

Mei-Huei Chen

Kai-Ping Chen

Li-Ling Liaw

Ming-Der Wu

Su-Hui Chuang

Ming-Jen Cheng

Shie-Jea Lin

Chih-Lu Wu

Hui-Ping Chen

Ching-Ping Tseng

Ping-Hsun Yang

Ting-Kuo Huang

Hsuen-Chun Liao

Wen-Jung Wu

Chung-Tsai Lee

Yi-Pei Chen

Chun-Lin Wang

I-Ching Chen

Ta-Wei Liu

Shiaw-Min Hwang

Min Tseng

Yu-Shan Lin

Chien-Cho Chen

Shiow-Wen Chen

Wen-Teng Wu

Pei-Ming Wang

Jian-Chyi Chen

Chi-Hua Chen

Ping-Shin Yang

Hsueh-O Chang

Shu-Wan Wang

Kim-Chi Hoang

Ming-Chih Lin

Shu-Feng Yang

Jyh-Wei Chen

Hasiao Chi Peng

En-Hui Kuo

Yi-Ju Liu

The present invention relates to a monascuspurpurone compound of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPAR&#x3b3; and/or C/EBP&#x3b1;, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.

Monascuspurpurones, preparation and uses thereof

The present invention relates to a novel monascuspurpurone compound of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPAR&#x3b3; and/or C/EBP&#x3b1;, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.

Monascuspurpurones, preparation process thereof, and uses of the monascuspurpurones

The present invention relates to novel pyridine alkaloid compounds of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for the preparation of the same, and the composition comprising the same. The uses of a pyridine compound for increasing the activity of PPAR&#x3b3;, for the prevention and/or treatment of a disease or disorder related to insulin resistance, and for the prevention and/or treatment of metabolic syndrome or its complication are also provided. The invention also provides extracts of red yeast-fermented products and their uses for prevention and/or treatment of a disease or disorder related to insulin resistance, such as metabolic syndrome.

Pyridine alkaloids, preparation process thereof, and the uses of the pyridine alkaloids

The present invention concerns the uses of an azaphilone compound of formula (I): formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification for modulation of the activity of a nuclear hormone receptor and for prevention and/or treatment of a disease or disorder related to nuclear hormone receptor activity.

Use of azaphilone compounds for the modulation of the activity of a nuclear hormone receptor

A new thermotolerantsp., which is capable of degrading polyesters, is provided. Compositions comprising the species for use in degrading polyesters are also provided. The invention also relates to methods for degrading polyesters by using the strain and the composition.

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Promoters and usage thereof. Two promoters, acuF and hsp promoters, comprise the nucleotide sequences of SEQ ID NO: 1 and 2, respectively.

Promoters and usage thereof

Cholesterol inhibitor produced by, monacolin k, is a secondary metabolite of polyketides. The invention provides probes specific to monacolin k biosynthesis gene cluster. BAC clones having putative monacolin k gene cluster were screened from BAC (bacterial artificial chromosome) library, and sequencing and annotation were performed on these clones. The results show that 2 polyketide synthase (PKS) genes and 7 regulatory genes related to monacolin k synthesis were obtained. Full-length cDNAs of these genes were then obtained by RT-PCR and cloned to expression vectors for the expression of these genes.

Monacolin K biosynthesis genes

Retrotransposons and methods related thereto. The retrotransposon comprises a nucleotide sequence selected from a group consisting of a nucleotide sequence of SEQ ID NO: 1, a nucleotide sequence of SEQ ID NO: 2, a nucleotide sequence of SEQ ID NO: 3, and a nucleotide sequence encoding a polypeptide of an amino acid sequence of SEQ ID NO: 4.

Fungi non-LTR retrotransposons and methods related thereto

A chitosan having a weight average molecular weight of 50,000-140,000 g/mole and a degree of deacetylation of 85-95%. Also disclosed are a method of preparing a chitosan from a fungus, and a method of using a chitosan for treating breast or cervical cancer.

Chitosans

The invention discloses a method for cultivation of filamentous fungi using a suspended nutritionally solid substrate, the method including the steps of: (a) preparing a medium comprising a nutritionally solid substrate; and (b) inoculating an inoculum into the medium comprising the nutritionally solid substrate in a bioreactor to carry out fermentation. The present invention combines the properties of solid-state culture and submerged culture. In addition, the present invention may employ an air-lift bioreactor with a net draft tube and the fed-batch process to elevate the yields of filamentous fungi and metabolites thereof.

Method for cultivation of filamentous fungi

The invention relates to a mutant of , designated as M011, which is useful in the production of yellow pigments with a low amount of citrinin.

Monascus purpureus mutant and its use in preparing yellow pigment

The invention relates to a method of producing chitin or chitosan by culturing a fungus or an fungus and isolating chitosan or chitin from the culture.

Production of chitosan and chitin

The invention relates to a method of producing chitin or chitosan by culturing a,fungus or an,fungus and isolating chitosan or chitin from the culture.

Growing community of inventors

Hsinchu, Taiwan

Gwo-Fang Yuan