Institut National De La Sante Et De La Recherche Medicale

Institut National De La Recherche Agronomique

Université De Rennes 1

Institut National De La Recherche Agronomique (inra)

Institut Pasteur De Lille (ipl)

Institut Pasteur De Lille

Gwenael Jan

Marie-Thérèse Dimanche-Boitrel

Hélène Falentin

Benoit Foligne

Stephanie-Marie Deutsch

Charles Halouze

Stéphanie-Marie Deutsch

Disclosed is a polypeptide including or consisting of the amino acid sequence SEQ id n:1, for use in the treatment or prevention of an inflammatory disease. It further encompasses a nucleic acid sequence encoding a polypeptide, a vector including a nucleic acid and a host cell including a nucleic acid sequence and/or a vector, for use in the treatment or prevention of an inflammatory disease. Also disclosed is a pharmaceutical composition or a food composition including a polypeptide, a nucleic acid sequence, a vector or a host cell and a pharmaceutically acceptable carrier or a dairy product, for the treatment of inflammatory disease. Additionally, a method for the screening of bacteria having immunomodulatory properties is disclosed.

Anti-inflammatory properties of a surface protein of propionibacterium freudenreichii

The present invention relates to a recombinant vector for expressing and secreting, by a, at least one eukaryotic peptide or protein of interest, comprising at least: under the control of at least one suitable promoter, at least one nucleic acid sequence encoding a propionibacterial signal peptide and, at least one nucleic acid sequence encoding said eukaryotic peptide or protein of interest; wherein said at least one nucleic acid sequence encoding a propionibacterial signal peptide is translationally fused to said at least one nucleic acid sequence encoding said eukaryotic peptide or protein of interest. The invention further relates to the uses of such a vector in the pharmaceutical field or for the large-scale production of peptides or proteins of interest.

Recombinant vector for producing and secreting peptide or protein of interest by propionibacteria and applications thereof

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Rennes, France

Gwenael Jan